BiDil (Isosorbide Dinitrate and Hydralazine Hcl) Drug Information: Description, User Reviews, Drug Side Effects, Interactions

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February 10, 2012

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BiDil

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BiDil®
(isosorbide dinitrate and hydralazine hydrochloride) Tablets

DRUG DESCRIPTION

BiDil (isosorbide dinitrate and hydralazine hcl) is a fixed-dose combination of isosorbide dinitrate,a vasodilator with effects on both arteries and veins,and hydralazine hydrochloride,a predominantly arterial vasodilator.

Isosorbide dinitrate is described chemically as 1,4:3,6-dianhydro-d-glucitol-2,5-dinitrate and its structural formula is:

Isosorbide dinitrate Structural Formula Illustration

Isosorbide dinitrate is a white to off-white,crystalline powder with the empirical formula C₆H₈N₂O₈ and a molecular weight of 236.14. It is freely soluble in organic solvents such as alcohol, chloroform and ether,but is only sparingly soluble in water.

Hydralazine hydrochloride is described chemically as 1-hydrazinophthalazine monohy-drochloride,and its structural formula is:

Hydralazine hydrochloride Structural Formula Illustration

Hydralazine HCl is a white to off-white,crystalline powder with the empirical formula C₈H₈N₄·HCl and a molecular weight of 196.64.It is soluble in water,slightly soluble in alcohol,and very slightly soluble in ether.

Each BiDil (isosorbide dinitrate and hydralazine hcl) Tablet for oral administration contains 20 mg of isosorbide dinitrate and 37.5 mg of hydralazine hydrochloride.

The inactive ingredients in BiDil (isosorbide dinitrate and hydralazine hcl) tablets include: anhydrous lactose, microcrystalline cellu-lose, sodium starch glycolate,colloidal silicon dioxide, magnesium stearate,hypromellose, FD&C Yellow No.6 aluminum lake,polyethylene glycol,titanium dioxide,polysorbate 80.

What are the possible side effects of hydralazine and isosorbide dinitrate (BiDil)?

If you experience any of the following serious side effects, stop taking hydralazine and isosorbide dinitrate and seek emergency medical attention:

an allergic reaction (difficulty breathing; closing of your throat; swelling of your lips, tongue, or face; or hives);
blurred vision and dry mouth;
irregular heartbeat; or
blood in your urine or stools;
numbness, tingling, pain, or weakness of your arms or legs;
fainting.

Other, less serious...

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What are the precautions when taking isosorbide dinitrate and hydralazine hcl (BiDil)?

Before taking this medication, tell your doctor or pharmacist if you are allergic to either isosorbide dinitrate or hydralazine; or to similar drugs (such as nitroglycerin); or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: other heart problems (such as recent heart attack, rheumatic heart disease of the mitral valve), previous stroke, low blood pressure, blood vessel problems, loss of too much body water (dehydration), recent head injury, anemia, kidney problems.

This drug may make you dizzy. Do not drive, use machinery, or do any activity that...

Read All Potential Precautions of BiDil »

Last reviewed on RxList: 10/7/2008
This monograph has been modified to include the generic and brand name in many instances.