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Biltricide

"According to the World Health Organization, in 2010, malaria caused an estimated 219 million illnesses and 660,000 deaths, mostly children under 5 years old in Africa. These numbers represent a 25% decrease in malaria deaths globally and a 33% re"...

Biltricide

CLINICAL PHARMACOLOGY

Praziquantel induces a rapid contraction of schistosomes by a specific effect on the permeability of the cell membrane. The drug further causes vacuolization and disintegration of the schistosome tegument.

After oral administration BILTRICIDE (praziquantel) is rapidly absorbed (80%), subjected to a first pass effect, metabolized and eliminated by the kidneys. Maximal serum concentration is achieved 1-3 hours after dosing. The half-life of praziquantel in serum is 0.8-1.5 hours.

Special Populations

The pharmacokinetics of praziquantel were studied in 40 patients with Schistosoma mansoni infections with varying degrees of hepatic dysfunction (See table 1). In patients with schistosomiasis, the pharmacokinetic parameters did not differ significantly between those with normal hepatic function (Group 1) and those with mild (Child-Pugh class A) hepatic impairment. However, in patients with moderate-to-severe hepatic dysfunction (Child-Pugh class B and C), praziquantel half-life, Cmax, and AUC increased progressively with the degree of hepatic impairment. In Child-Pugh class B, the increases in mean half-life, Cmax, and AUC relative to Group 1 were 1.58-fold, 1.76-fold, and 3.55-fold, respectively. The corresponding increases in Child-Pugh class C patients were 2.82-fold, 4.29-fold, and 15-fold for half-life, Cmax, and AUC.

Table 1: Pharmacokinetic parameters of praziquantel in four groups of patients with varying degrees of liver function following administration of 40 mg/kg under fasting conditions.

Patient Group Half-life (hr) Tmax (hr) Cmax (μg/mL) AUC (μg/mL* hr)
Normal hepatic function (Group 1) 2.99 ± 1.28 1.48 ±0.74 0.83 ± 0.52 3.02 ±0.59
Child-Pugh A (Group 2) 4.66±2.77 1.37 ± 0.61 0.93± 0.58 3.87 ±2.44
Child-Pugh B (Group 3) 4.74 ±2.16a 2.21 ± 0.78a,b 1.47 ±0.74a,b 10.72 ±5.53a,b
Child-Pugh C (Group 4) 8.45 ±2.62a,b,c 3.2 ± 1.05a,b,c 3.57 ±1.30a,b,c 45.35 ± 17.50a,b,c
a) p < 0.05 compared to Group 1
b) p < 0.05 compared to Group 2
c) p < 0.05 compared to Group 3

Last reviewed on RxList: 9/13/2010
This monograph has been modified to include the generic and brand name in many instances.

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