William C. Shiel Jr., MD, FACP, FACR
Dr. Shiel received a Bachelor of Science degree with honors from the University of Notre Dame. There he was involved in research in radiation biology and received the Huisking Scholarship. After graduating from St. Louis University School of Medicine, he completed his Internal Medicine residency and Rheumatology fellowship at the University of California, Irvine. He is board-certified in Internal Medicine and Rheumatology.
Melissa Conrad Stöppler, MD
Melissa Conrad Stöppler, MD, is a U.S. board-certified Anatomic Pathologist with subspecialty training in the fields of Experimental and Molecular Pathology. Dr. Stöppler's educational background includes a BA with Highest Distinction from the University of Virginia and an MD from the University of North Carolina. She completed residency training in Anatomic Pathology at Georgetown University followed by subspecialty fellowship training in molecular diagnostics and experimental pathology.
In this Article
- What are biologic rhythms?
- How does the "body clock" affects symptoms of illness?
- What are examples of specific diseases affected by biorhythms?
- Heart attack
- High blood pressure (hypertension)
- Hay fever (allergic rhinitis)
- Can the "body clock" affect diagnostic testing?
- Can drug therapy be matched to the "body clock?"
- Chronobiology: marking time, making progress
What are examples of specific diseases affected by biorhythms?
- Oxygenated blood is normally delivered to the heart muscle by arteries to the heart (coronary arteries).
- Inadequate oxygenation of
heart muscle (ischemia) can
occur because of either narrowing or spasm of the coronary arteries.
- Narrowing of the coronary arteries (coronary artery disease or CAD) is usually caused by
(cholesterol deposits on the inner wall of the arteries).
- In patients with narrowed coronary arteries, factors that increase work demand and oxygen consumption of the heart (such as exercise, excitement, increased blood pressure and heart rate) can precipitate heart muscle ischemia and angina.
Patients who develop angina only during stress or physical exertion have stable, exertional angina. When a coronary artery becomes critically narrowed, heart muscle ischemia or angina can occur with minimal or no exertion. These patients have unstable angina, and are at imminent risk of heart attack (myocardial infarction). A heart attack occurs when a diseased coronary artery becomes completely obstructed by a blood clot, leading to irreversible death of heart muscle. During the early hours of a heart attack, irregular heart rhythms can occur which commonly cause sudden cardiac death.
Heart ischemia resulting in angina can be caused by spasm of the coronary arteries. This is a rare condition called vasospastic angina (also known as Prinzmetal's angina) and is not associated with exertion.
It has been known for some time that the symptoms of ischemic heart disease are more common in the morning hours than at any other time of day.
- Patients experience episodes of stable angina with lower levels of exertion
in the morning than in the afternoon.
- The occurrence of episodes of vasospastic angina is higher in the morning
than in the afternoons.
- In patients with CAD, electrocardiogram (ECG) changes indicative of heart muscle ischemia are seen more frequently in the morning than in the afternoon.
Next: Heart attack
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