Black Pepper And White Pepper

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Are there any interactions with medications?



Lithium
Interaction Rating: Moderate Be cautious with this combination.
Talk with your health provider.

Black pepper and white pepper might have an effect like a water pill or "diuretic." Taking black pepper and white pepper might decrease how well the body gets rid of lithium. This could increase how much lithium is in the body and result in serious side effects. Talk with your healthcare provider before using this product if you are taking lithium. Your lithium dose might need to be changed.



Medications changed by the liver (Cytochrome P450 3A4 (CYP3A4) substrates)
Interaction Rating: Moderate Be cautious with this combination.
Talk with your health provider.

Some medications are changed and broken down by the liver. Black and white pepper might decrease how quickly the liver breaks down some medications. Taking pepper along with some medications that are broken down by the liver can increase the chance of side effects from some medications. Before taking black or white pepper, talk to your healthcare provider if you are taking any medications that are changed by the liver.

Some medications changed by the liver include lovastatin (Mevacor), ketoconazole (Nizoral), itraconazole (Sporanox), fexofenadine (Allegra), triazolam (Halcion), and many others.



Medications moved by pumps in cells (P-Glycoprotein Substrates)
Interaction Rating: Moderate Be cautious with this combination.
Talk with your health provider.

Some medications are moved by pumps in cells. Black and white pepper might make these pumps less active and increase how much of some medications get absorbed by the body. This might cause more side effects from some medications.

Some medications that are moved by these pumps include etoposide, paclitaxel, vinblastine, vincristine, vindesine, ketoconazole, itraconazole, amprenavir, indinavir, nelfinavir, saquinavir, cimetidine, ranitidine, diltiazem, verapamil, digoxin, corticosteroids, erythromycin, cisapride (Propulsid), fexofenadine (Allegra), cyclosporine, loperamide (Imodium), quinidine, and others.



Phenytoin (Dilantin)
Interaction Rating: Moderate Be cautious with this combination.
Talk with your health provider.

Black and white pepper might increase how much phenytoin (Dilantin) the body absorbs. Taking black and white pepper along with phenytoin (Dilantin) might increase the effects and side effects of phenytoin (Dilantin).



Propranolol (Inderal)
Interaction Rating: Moderate Be cautious with this combination.
Talk with your health provider.

Black and white pepper might increase how much propranolol (Inderal) the body absorbs. Taking black and white pepper along with propranolol (Inderal) might increase the effects and side effects of propranolol (Inderal).



Rifampin
Interaction Rating: Moderate Be cautious with this combination.
Talk with your health provider.

Black and white pepper might increase how much rifampin the body absorbs. Taking black and white pepper along with rifampin might increase the effects and side effects of rifampin.



Theophylline
Interaction Rating: Moderate Be cautious with this combination.
Talk with your health provider.

Black pepper and white pepper can increase how much theophylline the body can absorb. This might cause increased effects and side effects of theophylline.



Carbamazepine (Tegretol)
Interaction Rating: Minor Be cautious with this combination.
Talk with your health provider.

Black and white pepper might increase the amount of carbamazepine (Tegretol) absorbed by the body. It might also decrease how quickly the body breaks down and gets rid of carbamazepine. This could increase how much carbamazepine is in the body and potentially increase the chance of side effects. However, there is not enough known about this potential interaction to know if it is a big concern.

Dosing considerations for Black Pepper And White Pepper.

The appropriate dose of black pepper and white pepper for use as treatment depends on several factors such as the user's age, health, and several other conditions. At this time there is not enough scientific information to determine an appropriate range of doses for black pepper and white pepper. Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult your pharmacist or physician or other healthcare professional before using.


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