September 2, 2015

Black Tea

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Are there any interactions with medications?



Adenosine (Adenocard)
Interaction Rating: Moderate Be cautious with this combination.
Talk with your health provider.

Black tea contains caffeine. The caffeine in black tea might block the effects of adenosine (Adenocard). Adenosine (Adenocard) is often used by doctors to do a test on the heart. This test is called a cardiac stress test. Stop drinking black tea or other caffeine-containing products at least 24 hours before a cardiac stress test.



Antibiotics (Quinolone antibiotics)
Interaction Rating: Moderate Be cautious with this combination.
Talk with your health provider.

The body breaks down caffeine to get rid of it. Some antibiotics might decrease how quickly the body breaks down caffeine. Taking these antibiotics along with black tea can increase the risk of side effects including jitteriness, headache, increased heart rate, and other side effects.

Some antibiotics that decrease how quickly the body breaks down caffeine include ciprofloxacin (Cipro), enoxacin (Penetrex), norfloxacin (Chibroxin, Noroxin), sparfloxacin (Zagam), trovafloxacin (Trovan), and grepafloxacin (Raxar).



Benzodiazepines
Interaction Rating: Moderate Be cautious with this combination.
Talk with your health provider.

Benzodiazepines are drugs that have calming effects. Black tea contains caffeine. Caffeine is a stimulant. Taking black tea along with benzodiazepines might block the calming effects of can benzodiazepines. Some benzodiazepines include alprazolam (Xanax), clonazepam (Klonopin), diazepam (Valium), lorazepam (Ativan), and others.



Carbamazepine (Tegretol)
Interaction Rating: Moderate Be cautious with this combination.
Talk with your health provider.

Carbamazepine is a drug used to treat seizures. Caffeine in black tea can decrease the effects of carbamazepine. Taking black tea with carbamazepine might decrease the effects of carbamazepine and increase the risk of seizures in some people.



Cimetidine (Tagamet)
Interaction Rating: Moderate Be cautious with this combination.
Talk with your health provider.

Black tea contains caffeine. The body breaks down caffeine to get rid of it. Cimetidine (Tagamet) can decrease how quickly your body breaks down caffeine. Taking cimetidine (Tagamet) along with black tea might increase the chance of caffeine side effects including jitteriness, headache, fast heartbeat, and others.



Clozapine (Clozaril)
Interaction Rating: Moderate Be cautious with this combination.
Talk with your health provider.

The body breaks down clozapine (Clozaril) to get rid of it. The caffeine in black tea seems to decrease how quickly the body breaks down clozapine (Clozaril). Taking black tea along with clozapine (Clozaril) can increase the effects and side effects of clozapine (Clozaril).



Dipyridamole (Persantine)
Interaction Rating: Moderate Be cautious with this combination.
Talk with your health provider.

Black tea contains caffeine. The caffeine in black tea might block the affects of dipyridamole (Persantine). Dipyridamole (Persantine) is often used by doctors to do a test on the heart. This test is called a cardiac stress test. Stop drinking black tea or other caffeine-containing products at least 24 hours before a cardiac stress test.



Disulfiram (Antabuse)
Interaction Rating: Moderate Be cautious with this combination.
Talk with your health provider.

The body breaks down caffeine to get rid of it. Disulfiram (Antabuse) can decrease how quickly the body gets rid of caffeine. Taking black tea (which contains caffeine) along with disulfiram (Antabuse) might increase the effects and side effects of caffeine including jitteriness, hyperactivity, irritability, and others.



Ephedrine
Interaction Rating: Moderate Be cautious with this combination.
Talk with your health provider.

Stimulant drugs speed up the nervous system. Black tea contains caffeine. Caffeine and ephedrine are both stimulant drugs. Taking black tea along with ephedrine might cause too much stimulation and sometimes serious side effects and heart problems. Do not take caffeine containing products and ephedrine at the same time.



Estrogens
Interaction Rating: Moderate Be cautious with this combination.
Talk with your health provider.

The body breaks down the caffeine in black tea to get rid of it. Estrogens can decrease how quickly the body breaks down caffeine. Taking estrogen pills and drinking black tea can cause jitteriness, headache, fast heartbeat, and other side effects. If you take estrogen pills, limit your caffeine intake.

Some estrogen pills include conjugated equine estrogens (Premarin), ethinyl estradiol, estradiol, and others.



Ethosuximide
Interaction Rating: Moderate Be cautious with this combination.
Talk with your health provider.

Ethosuximide is a drug used to treat seizures. Caffeine in black tea can decrease the effects of ethosuximide. Taking black tea with ethosuximide might decrease the effects of ethosuximide and increase the risk of seizures in some people.



Felbamate
Interaction Rating: Moderate Be cautious with this combination.
Talk with your health provider.

Felbamate is a drug used to treat seizures. Caffeine in black tea can decrease the effects of felbamate. Taking black tea with felbamate might decrease the effects of felbamate and increase the risk of seizures in some people.



Flutamide (Eulexin)
Interaction Rating: Moderate Be cautious with this combination.
Talk with your health provider.

The body breaks down flutamide (Eulexin) to get rid of it. Caffeine in black tea might decrease how quickly the body gets rid of flutamide. This could cause flutamide to stay in the body too long and increase the risk of side effects.



Fluvoxamine (Luvox)
Interaction Rating: Moderate Be cautious with this combination.
Talk with your health provider.

The body breaks down the caffeine in black tea to get rid of it. Fluvoxamine (Luvox) can decrease how quickly the body breaks down caffeine. Taking caffeine along with fluvoxamine (Luvox) might cause too much caffeine in the body, and increase the effects and side effects of caffeine.



Lithium
Interaction Rating: Moderate Be cautious with this combination.
Talk with your health provider.

Your body naturally gets rid of lithium. The caffeine in black tea can increase how quickly your body gets rid of lithium. If you take products that contain caffeine and you take lithium, stop taking caffeine products slowly. Stopping caffeine too quickly can increase the side effects of lithium.



Medications for asthma (Beta-adrenergic agonists)
Interaction Rating: Moderate Be cautious with this combination.
Talk with your health provider.

Black tea contains caffeine. Caffeine can stimulate the heart. Some medications for asthma can also stimulate the heart. Taking caffeine with some medications for asthma might cause too much stimulation and cause heart problems.

Some medications for asthma include albuterol (Proventil, Ventolin, Volmax), metaproterenol (Alupent), terbutaline (Bricanyl, Brethine), and isoproterenol (Isuprel).



Medications for depression (MAOIs)
Interaction Rating: Moderate Be cautious with this combination.
Talk with your health provider.

The caffeine in black tea can stimulate the body. Some medications used for depression can also stimulate the body. Drinking black tea and taking some medications for depression might cause too much stimulation of the body and serious side effects including fast heartbeat, high blood pressure, nervousness, and others.

Some of these medications used for depression include phenelzine (Nardil), tranylcypromine (Parnate), and others.



Medications that change the liver (Cytochrome P450 1A2 (CYP1A2) inhibitors)
Interaction Rating: Moderate Be cautious with this combination.
Talk with your health provider.

Black tea contains caffeine. Caffeine is broken down by the liver. Some medications decrease how well the liver breaks down other medications. These medications that change the liver might decrease how fast caffeine in black tea is broken down in the body. This might increase the effects and side effects of caffeine in black tea. Some medications that change the liver include cimetidine (Tagamet), ciprofloxacin (Cipro), fluvoxamine (Luvox), and others.



Medications that slow blood clotting (Anticoagulant / Antiplatelet drugs)
Interaction Rating: Moderate Be cautious with this combination.
Talk with your health provider.

Black tea contains caffeine. Caffeine might slow blood clotting. Taking black tea along with medications that also slow clotting might increase the chances of bruising and bleeding.

Some medications that slow blood clotting include aspirin, clopidogrel (Plavix), diclofenac (Voltaren, Cataflam, others), ibuprofen (Advil, Motrin, others), naproxen (Anaprox, Naprosyn, others), dalteparin (Fragmin), enoxaparin (Lovenox), heparin, warfarin (Coumadin), and others.



Nicotine
Interaction Rating: Moderate Be cautious with this combination.
Talk with your health provider.

Black tea contains caffeine. Caffeine can stimulate the heart. Nicotine can also stimulate the heart. Taking caffeine with nicotine might cause too much stimulation and cause heart problems, such as increased heart rate or blood pressure.



Pentobarbital (Nembutal)
Interaction Rating: Moderate Be cautious with this combination.
Talk with your health provider.

The stimulant effects of the caffeine in black tea can block the sleep-producing effects of pentobarbital.



Phenobarbital
Interaction Rating: Moderate Be cautious with this combination.
Talk with your health provider.

Phenobarbital is a drug used to treat seizures. Caffeine in black tea can decrease the effects of phenobarbital. Taking black tea with phenobarbital might decrease the effects of phenobarbital and increase the risk of seizures in some people.



Phenylpropanolamine
Interaction Rating: Moderate Be cautious with this combination.
Talk with your health provider.

The caffeine in black tea can stimulate the body. Phenylpropanolamine can also stimulate the body. Taking caffeine and phenylpropanolamine together might cause too much stimulation and increase heartbeat, blood pressure, and cause nervousness.



Phenytoin
Interaction Rating: Moderate Be cautious with this combination.
Talk with your health provider.

Phenytoin is a drug used to treat seizures. Caffeine in black tea can decrease the effects of phenytoin. Taking black tea with phenytoin might decrease the effects of phenytoin and increase the risk of seizures in some people.



Riluzole (Rilutek)
Interaction Rating: Moderate Be cautious with this combination.
Talk with your health provider.

The body breaks down riluzole (Rilutek) to get rid of it. Drinking black tea can decrease how quickly the body breaks down riluzole (Rilutek) and increase the effects and side effects of riluzole.



Stimulant drugs
Interaction Rating: Moderate Be cautious with this combination.
Talk with your health provider.

Stimulant drugs speed up the nervous system. By speeding up the nervous system, stimulant medications can make you feel jittery and speed up your heartbeat. The caffeine in black tea can also speed up the nervous system. Drinking black tea along with stimulant drugs might cause serious problems including increased heart rate and high blood pressure. Avoid taking stimulant drugs along with black tea.

Some stimulant drugs include diethylpropion (Tenuate), epinephrine, phentermine (Ionamin), pseudoephedrine (Sudafed), and many others.



Theophylline
Interaction Rating: Moderate Be cautious with this combination.
Talk with your health provider.

Black tea contains caffeine. Caffeine works similarly to theophylline. Caffeine can also decrease how quickly the body gets rid of theophylline. This might cause increased effects and side effects of theophylline.



Valproate
Interaction Rating: Moderate Be cautious with this combination.
Talk with your health provider.

Valproate is a drug used to treat seizures. Caffeine in black tea can decrease the effects of valproate. Taking black tea with valproate might decrease the effects of valproate and increase the risk of seizures in some people.



Verapamil (Calan, Covera, Isoptin, Verelan)
Interaction Rating: Moderate Be cautious with this combination.
Talk with your health provider.

The body breaks down the caffeine in black tea to get rid of it. Verapamil (Calan, Covera, Isoptin, Verelan) can decrease how quickly the body gets rid of caffeine. Drinking black tea and taking verapamil (Calan, Covera, Isoptin, Verelan) can increase the risk of side effects for caffeine including jitteriness, headache, and an increased heartbeat.



Warfarin (Coumadin)
Interaction Rating: Moderate Be cautious with this combination.
Talk with your health provider.

Warfarin (Coumadin) is used to slow blood clotting. Large amounts of black tea might decrease how well warfarin (Coumadin) slows blood clotting. Decreasing how well warfarin (Coumadin) slows blood clotting might increase the risk of clotting. It is unclear why this interaction might occur. Be sure to have your blood checked regularly. The dose of your warfarin (Coumadin) might need to be changed.



Water pills (Diuretic drugs)
Interaction Rating: Moderate Be cautious with this combination.
Talk with your health provider.

Black tea contains caffeine. Caffeine, especially in excessive amounts, can reduce potassium in the body. "Water pills" can also decrease potassium in the body. Taking caffeine-containing products along with "water pills" might decrease potassium in the body too much.

Some "water pills" that can decrease potassium include chlorothiazide (Diuril), chlorthalidone (Thalitone), furosemide (Lasix), hydrochlorothiazide (HCTZ, HydroDIURIL, Microzide), and others.



Alcohol
Interaction Rating: Minor Be cautious with this combination.
Talk with your health provider.

Black tea contains caffeine. The body breaks down the caffeine in black tea to get rid of it. Alcohol can decrease how quickly the body breaks down caffeine. Taking black tea along with alcohol might cause too much caffeine in the bloodstream and caffeine side effects including jitteriness, headache, and fast heartbeat.



Birth control pills (Contraceptive drugs)
Interaction Rating: Minor Be cautious with this combination.
Talk with your health provider.

Black tea contains caffeine. The body breaks down caffeine to get rid of it. Birth control pills can decrease how quickly the body breaks down caffeine. Taking black tea along with birth control pills might cause jitteriness, headache, fast heartbeat, and other side effects.

Some birth control pills include ethinyl estradiol and levonorgestrel (Triphasil), ethinyl estradiol and norethindrone (Ortho-Novum 1/35, Ortho-Novum 7/7/7), and others.



Fluconazole (Diflucan)
Interaction Rating: Minor Be cautious with this combination.
Talk with your health provider.

Black tea contains caffeine. The body breaks down caffeine to get rid of it. Fluconazole (Diflucan) might decrease how quickly the body gets rid of caffeine. This could cause caffeine to stay in the body too long and increase the risk of side effects such as nervousness, anxiety, and insomnia.



Medications for depression (Tricyclic antidepressants)
Interaction Rating: Minor Be cautious with this combination.
Talk with your health provider.

Black tea contains chemicals called tannins. Tannins can bind to many medications and decrease how much medicine the body absorbs. To avoid this interaction, avoid black tea 1 hour before and 2 hours after taking medications for depression called tricyclic antidepressants.

Some medications for depression include amitriptyline (Elavil) or imipramine (Tofranil, Janimine).



Medications for diabetes (Antidiabetes drugs)
Interaction Rating: Minor Be cautious with this combination.
Talk with your health provider.

Black tea contains caffeine. Caffeine might increase blood sugar. Diabetes medications are used to lower blood sugar. By increasing blood sugar, black tea might decrease the effectiveness of diabetes medications. Monitor your blood sugar closely. The dose of your diabetes medication might need to be changed.

Some medications used for diabetes include glimepiride (Amaryl), glyburide (DiaBeta, Glynase PresTab, Micronase), insulin, pioglitazone (Actos), rosiglitazone (Avandia), chlorpropamide (Diabinese), glipizide (Glucotrol), tolbutamide (Orinase), and others.



METFORMIN (Glucophage)
Interaction Rating: Minor Be cautious with this combination.
Talk with your health provider.

Black tea contains caffeine. The body breaks down caffeine to get rid of it. Metformin (Glucophage) can decrease how quickly the body breaks down caffeine. Taking black tea along with metformin might cause too much caffeine in the body, and increase the effects and side effects of caffeine.



Methoxsalen (Oxsoralen)
Interaction Rating: Minor Be cautious with this combination.
Talk with your health provider.

Black tea contains caffeine. The body breaks down caffeine to get rid of it. Methoxsalen (Oxsoralen) can decrease how quickly the body breaks down caffeine. Taking caffeine along with methoxsalen might cause too much caffeine in the body, and increase the effects and side effects of caffeine.



Mexiletine (Mexitil)
Interaction Rating: Minor Be cautious with this combination.
Talk with your health provider.

Black tea contains caffeine. The body breaks down caffeine to get rid of it. Mexiletine (Mexitil) can decrease how quickly the body breaks down caffeine. Taking Mexiletine (Mexitil) along with black tea might increase the caffeine effects and side effects of black tea.



Phenothiazines
Interaction Rating: Minor Be cautious with this combination.
Talk with your health provider.

Black tea contains chemicals called tannins. Tannins can bind to many medications and decrease how much medicine the body absorbs. To avoid this interaction, avoid black tea one hour before and two hours after taking phenothiazine medications.

Some phenothiazine medications include fluphenazine (Permitil, Prolixin), chlorpromazine (Thorazine), haloperidol (Haldol), prochlorperazine (Compazine), thioridazine (Mellaril), and trifluoperazine (Stelazine).



Terbinafine (Lamisil)
Interaction Rating: Minor Be cautious with this combination.
Talk with your health provider.

The body breaks down the caffeine in black tea to get rid of it. Terbinafine (Lamisil) can decrease how quickly the body gets rid of caffeine and increase the risk of side effects including jitteriness, headache, increased heartbeat, and other effects.



Tiagabine
Interaction Rating: Minor Be cautious with this combination.
Talk with your health provider.

Black tea contains caffeine. Taking caffeine over a long time period along with tiagabine can increase the amount of tiagabine in the body. This might increase the side effects of tiagabine.



Ticlopidine (Ticlid)
Interaction Rating: Minor Be cautious with this combination.
Talk with your health provider.

The body breaks down the caffeine in black tea to get rid of it. Ticlopidine (Ticlid) can decrease how quickly the body gets rid of caffeine. Taking black tea along with ticlopidine might increase the effects and side effects of caffeine, including jitteriness, hyperactivity, irritability, and others.

Dosing considerations for Black Tea.

An 8-ounce serving of black tea provides from 40-120 mg of caffeine, the active ingredient.

The following doses have been studied in scientific research:

BY MOUTH:
  • For headache or improving mental alertness: a typical dose is up to 250 mg of caffeine (several cups of black tea) per day.
  • For reducing the risk of heart attack and kidney stones: a dose of at least one cup per day.
  • For preventing "hardening of the arteries" (atherosclerosis), 125-500 mL (1-4 cups) of brewed black tea daily.
  • For preventing Parkinson's disease: men drinking 421-2716 mg of total caffeine (approximately 5-33 cups of black tea) daily have the lowest risk of developing Parkinson's disease, when compared to other men. However, men who drink as little as 124-208 mg of caffeine (approximately 1-3 cups of black tea) daily also have a significantly lower chance of developing Parkinson's disease. In women, moderate caffeine intake (1-4 cups of black tea) per day seems to be best.

Therapeutic Research Faculty copyright

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