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Raynaud's phenomenon (RP) is a condition resulting in a particular series of discolorations of the fingers and/or the toes after exposure to changes in temperature (cold or hot) or emotional events. Skin discoloration occurs because an abnormal spasm of the blood vessels causes a diminished blood supply to the local tissues. Initially, the digit(s) involved turn white because of the diminished blood supply. The digit(s) then turn blue because of prolonged lack of oxygen. Finally, the blood vessels reopen, causing a local "flushing" phenomenon, which turns the digit(s) red. This three-phase color sequence (white to blue to red), most often upon exposure to cold temperature, is characteristic of RP.
Raynaud's phenomenon most frequently affects women, especially in the second, third, or fourth decades of life. People can have Raynauds phenomenon alone or as a part of other rheumatic diseases. When it occurs alone...
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You should not receive bleomycin if you have ever had an allergic reaction to it.
If you have certain conditions, you may need a dose adjustment or special tests to safely use this medication. Before receiving bleomycin, tell your doctor if you have:
FDA pregnancy category D. Do not receive bleomycin without telling your doctor if you are pregnant. It could harm the unborn baby. Use effective birth control, and tell your doctor if you become pregnant during treatment.
It is not known whether bleomycin passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.
Bleomycin is given as an injection through a needle placed into a vein or muscle, or as a shot given under the skin When treating pleural effusion, bleomycin is given through a chest tube. You will receive this injection in a clinic or hospital setting.
Bleomycin is usually given once or twice per week, depending on the condition being treated. Follow your doctor's instructions.
To be sure this medication is not causing harmful effects on your lungs, you may need to have chest X-rays or other lung function tests on a regular basis. Do not miss any follow-up visits to your doctor for X-rays or other tests.
If you need to have any type of surgery, tell the surgeon ahead of time that you are being treated with bleomycin.
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You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
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