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No cases of overdose were reported in premarketing studies with BONIVA Injection. Overdosage with intravenous bisphosphonates may result in hypocalcemia, hypophosphatemia, and hypomagnesemia. Clinically relevant reductions in serum levels of calcium, phosphorus, and magnesium should be corrected by intravenous administration of calcium gluconate, potassium or sodium phosphate, and magnesium sulfate, respectively.
Dialysis would not be beneficial unless it is administered within 2 hours following the overdose.
Boniva is contraindicated in patients with the following conditions:
- Hypocalcemia [see WARNINGS AND PRECAUTIONS]
- Known hypersensitivity to BONIVA Injection or to any of its excipients. Cases of anaphylaxis, including fatal events, have been reported. [see WARNINGS AND PRECAUTIONS, ADVERSE REACTIONS]
Last reviewed on RxList: 4/7/2015
This monograph has been modified to include the generic and brand name in many instances.
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