Boostrix (Tetanus Toxoid, Reduced Diphtheria Toxoid and Acellular Pertussis Vaccine, Adsorbed) Drug Information: Description, User Reviews, Drug Side Effects, Interactions

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May 26, 2012

Boostrix

Whooping Cough (Pertussis) »

Whooping cough (pertussis) facts

Whooping cough (pertussis) is an acute, highly contagious respiratory infection that is caused by the bacterium Bordetella pertussis.
Whooping cough commonly affects infants and young children but can be prevented by immunization with pertussis vaccine.
Adults may develop whooping cough as their immunity from childhood vaccines wears off over time.
Clinical symptoms occur in three stages; the characteristic bursts of coughing are observed in the second, or paroxysmal, stage.
Antibiotics can help reduce the severity of the disease when administered early in the course of the disease.
Secondary bacterial pneumonia is the most common complication of whooping cough.

What is whooping cough? What is the history of whooping cough?

Whooping cough is a bacterial upper respiratory infection that leads to episodes of violent coughing. The d...

Read the Whooping Cough (Pertussis) article »

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Boostrix

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BOOSTRIX
(tetanus toxoid, reduced diphtheria toxoid and accllular pertussis vaccine, adsorbed) Suspension for Intramuscular Injection

DRUG DESCRIPTION

BOOSTRIX (Tetanus Toxoid, Reduced Diphtheria Toxoid and Acellular Pertussis Vaccine, Adsorbed) is a noninfectious, sterile, vaccine for intramuscular administration. It contains tetanus toxoid, diphtheria toxoid, and pertussis antigens (inactivated pertussis toxin [PT] and formaldehyde-treated filamentous hemagglutinin [FHA] and pertactin). The antigens are the same as those in INFANRIX, but BOOSTRIX is formulated with reduced quantities of these antigens.

Tetanus toxin is produced by growing Clostridium tetani in a modified Latham medium derived from bovine casein. The diphtheria toxin is produced by growing Corynebacterium diphtheriae in Fenton medium containing a bovine extract. The bovine materials used in these extracts are sourced from countries which the United States Department of Agriculture (USDA) has determined neither have nor are at risk of bovine spongiform encephalopathy (BSE). Both toxins are detoxified with formaldehyde, concentrated by ultrafiltration, and purified by precipitation, dialysis, and sterile filtration.

The acellular pertussis antigens (PT, FHA, and pertactin) are isolated from Bordetella pertussis culture grown in modified Stainer-Scholte liquid medium. PT and FHA are isolated from the fermentation broth; pertactin is extracted from the cells by heat treatment and flocculation. The antigens are purified in successive chromatographic and precipitation steps. PT is detoxified using glutaraldehyde and formaldehyde. FHA and pertactin are treated with formaldehyde.

Each antigen is individually adsorbed onto aluminum hydroxide. Each 0.5-mL dose is formulated to contain 5 Lf of tetanus toxoid, 2.5 Lf of diphtheria toxoid, 8 mcg of inactivated PT, 8 mcg of FHA, and 2.5 mcg of pertactin (69 kiloDalton outer membrane protein).

Tetanus and diphtheria toxoid potency is determined by measuring the amount of neutralizing antitoxin in previously immunized guinea pigs. The potency of the acellular pertussis components (inactivated PT and formaldehyde-treated FHA and pertactin) is determined by enzyme-linked immunosorbent assay (ELISA) on sera from previously immunized mice.

Each 0.5-mL dose contains aluminum hydroxide as adjuvant (not more than 0.39 mg aluminum by assay), 4.5 mg of sodium chloride, ≤ 100 mcg of residual formaldehyde, and ≤ 100 mcg of polysorbate 80 (Tween 80).

BOOSTRIX is available in vials and 2 types of prefilled syringes. One type of prefilled syringe has a tip cap which may contain natural rubber latex and a plunger which does not contain latex. The other type has a tip cap and a rubber plunger which contain dry natural latex rubber. The vial stopper does not contain latex. [See HOW SUPPLIED, Storage and Handling.]

What are the possible side effects of tetanus, diphtheria, acellular pertussis vaccine (Adacel (Tdap), Boostrix (Tdap))?

You should not receive this vaccine a second time if you had a life-threatening allergic reaction after the first shot.

Keep track of any and all side effects you have after receiving this vaccine. If you ever have to receive another vaccine in the future, you will need to tell the doctor if the first shot caused any side effects.

Becoming infected with diphtheria, pertussis, or tetanus is much more dangerous to your health than receiving the vaccine to protect against these...

Read All Potential Side Effects and See Pictures of Boostrix »

What are the precautions when taking tetanus toxoid, reduced diphtheria toxoid and acellular pertussis vaccine, adsorbed (Boostrix)?

Before receiving this vaccination, tell your doctor or pharmacist if you are allergic to it; or to any other vaccines; or if you have any other allergies. This product may contain inactive ingredients (such as latex), which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

This medication should not be used if you have certain medical conditions. Before using this medicine, consult your doctor or pharmacist if you have: illness or infection with high fever, uncontrolled seizures or other nervous system disorder (e.g., encephalopathy).

Before using this medication, tell your doctor or pharmacist your medical history, especially of: bleeding disorders, history of Guillain-Barre syndrome, immune system disorders (e.g., autoimmune...

Read All Potential Precautions of Boostrix »

Last reviewed on RxList: 7/21/2011
This monograph has been modified to include the generic and brand name in many instances.