Brevibloc (Esmolol) Drug Overview and Uses for Patients and Caregivers at RxList

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May 25, 2012

Brevibloc

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High blood pressure facts

High blood pressure (hypertension) is designated as either essential (primary) hypertension or secondary hypertension and is defined as a consistently elevated blood pressure exceeding 140/90 mm Hg.
High blood pressure is called "the silent killer" because it often causes no symptoms for many years, even decades, until it finally damages certain critical organs.
Poorly controlled high blood pressure ultimately can cause damage to blood vessels in the eye, thickening of the heart muscle and heart attacks, hardening of the arteries (arteriosclerosis), kidney failure, and strokes.
Most antihypertensive medications can be used alone or in combination. Some are used only in combination. Some are preferred over others in certain specific medical situations. And some are not to be used (contraindicated) in other situations.
Several classes of antihypertensive medications are available, including ACE i...

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Brevibloc

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BREVIBLOC PREMIXED INJECTION
(esmolol hydrochloride)
2,500 mg/250 mL (10 mg/mL) Ready-to-use Bags
250 mL Bags
Iso-Osmotic Solution of Esmolol Hydrochloride in Sodium Chloride
For Intravenous Use Can be used for direct intravenous use.
Esmolol Hydrochloride concentration = 10 milligrams/mL (10,000 micrograms/mL)
Single Patient Use Only
No Preservatives Added

BREVIBLOC DOUBLE STRENGTH PREMIXED INJECTION
(esmolol hydrochloride)
2,000 mg/100 mL (20 mg/mL) Ready-to-use Bags
100 mL Bags
Iso-Osmotic Solution of Esmolol Hydrochloride in Sodium Chloride
For Intravenous Use
Can be used for direct intravenous use.
Esmolol Hydrochloride concentration = 20 milligrams/mL (20,000 micrograms/mL)
Single Patient Use Only
No Preservatives Added

BREVIBLOC INJECTION
(esmolol hydrochloride)
100 mg/10 mL (10 mg/mL) Ready-to-use Vials
10 mL Vials
Iso-Osmotic Solution of Esmolol Hydrochloride in Sodium Chloride
For Intravenous Use
Can be used for direct intravenous use.
Esmolol Hydrochloride concentration = 10 milligrams/mL (10,000 micrograms/mL)
Single Patient Use Only
No Preservatives Added

BREVIBLOC DOUBLE STRENGTH INJECTION
(esmolol hydrochloride)
100 mg/5 mL (20 mg/mL) Ready-to-use Vials
5 mL Vials
Iso-Osmotic Solution of Esmolol Hydrochloride in Sodium Chloride
For Intravenous Use
Can be used for direct intravenous use.
Esmolol Hydrochloride concentration = 20 milligrams/mL (20,000 micrograms/mL)
Single Patient Use Only
No Preservatives Added

DRUG DESCRIPTION

BREVIBLOC (Esmolol Hydrochloride) is a beta₁-selective (cardioselective) adrenergic receptor blocking agent with a very short duration of action (elimination half-life is approximately 9 minutes). Esmolol Hydrochloride is:

(±)-Methyl p-[2-hydroxy-3-(isopropylamino) propoxy] hydrocinnamate hydrochloride and has the following structure:

BREVIBLOC (Esmolol Hydrochloride) structural formula illustration

Esmolol Hydrochloride has the empirical formula C₁₆H₂₆NO₄Cl and a molecular weight of 331.8. It has one asymmetric center and exists as an enantiomeric pair.

Esmolol Hydrochloride is a white to off-white crystalline powder. It is a relatively hydrophilic compound which is very soluble in water and freely soluble in alcohol. Its partition coefficient (octanol/water) at pH 7.0 is 0.42 compared to 17.0 for propranolol.

Brevibloc Premixed Injection (esmolol)

BREVIBLOC PREMIXED INJECTION (esmolol) is a clear, colorless to light yellow, sterile, nonpyrogenic, iso-osmotic solution of esmolol hydrochloride in sodium chloride.

2500 mg, 250 mL Single Use Premixed Bag - Each mL contains 10 mg Esmolol Hydrochloride, 5.9 mg Sodium Chloride, USP and Water for Injection, USP; buffered with 2.8 mg Sodium Acetate Trihydrate, USP and 0.546 mg Glacial Acetic Acid, USP. Sodium Hydroxide and/or Hydrochloric Acid added, as necessary, to adjust pH to 5.0 (4.5-5.5). The calculated osmolarity is 312 mOsmol/L. The 250 mL bag is a non-latex, non-PVC IntraVia bag with dual PVC ports. The IntraVia bag is manufactured from a specially designed multilayer plastic (PL 2408). Solutions in contact with the plastic container leach out certain chemical compounds from the plastic in very small amounts; however, biological testing was supportive of the safety of the plastic container materials. See DOSAGE AND ADMINISTRATION, Directions for Use of the Premixed Bag for additional information.

2000 mg, 100 mL Single Use Premixed Bag DOUBLE STRENGTH - Each mL contains 20 mg Esmolol Hydrochloride, 4.1 mg Sodium Chloride, USP and Water for Injection, USP; buffered with 2.8 mg Sodium Acetate Trihydrate, USP and 0.546 mg Glacial Acetic Acid, USP. Sodium Hydroxide and/or Hydrochloric Acid added, as necessary, to adjust pH to 5.0 (4.5-5.5). The calculated osmolarity is 312 mOsmol/L. The 100 mL bag is a non-latex, non-PVC IntraVia bag with dual PVC ports. The IntraVia bag is manufactured from a specially designed multilayer plastic (PL 2408). Solutions in contact with the plastic container leach out certain chemical compounds from the plastic in very small amounts; however, biological testing was supportive of the safety of the plastic container materials. See DOSAGE AND ADMINISTRATION, Directions for Use of the Premixed Bag for additional information.

Brevibloc (esmolol) Injection

BREVIBLOC (esmolol) INJECTION is a clear, colorless to light yellow, sterile, nonpyrogenic, iso-osmotic solution of esmolol hydrochloride in sodium chloride.

100 mg, 10 mL Single Dose Vial - Each mL contains 10 mg Esmolol Hydrochloride, 5.9 mg Sodium Chloride, USP and Water for Injection, USP; buffered with 2.8 mg Sodium Acetate Trihydrate, USP and 0.546 mg Glacial Acetic Acid, USP. Sodium Hydroxide and/or Hydrochloric Acid added, as necessary to adjust pH to 5.0 (4.5-5.5).

100 mg, 5 mL DOUBLE STRENGTH Single Dose Vial - Each mL contains 20 mg Esmolol Hydrochloride, 4.1 mg Sodium Chloride, USP and Water for Injection, USP; buffered with 2.8 mg Sodium Acetate Trihydrate, USP and 0.546 mg Glacial Acetic Acid, USP. Sodium Hydroxide and/or Hydrochloric Acid added, as necessary to adjust pH to 5.0 (4.5-5.5).

Last reviewed on RxList: 12/3/2007
This monograph has been modified to include the generic and brand name in many instances.