November 27, 2015
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Brevital Sodium

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Brevital Sodium

Side Effects


Side effects associated with Brevital Sodium are extensions of pharmacologic effects and include:


Circulatory depression, thrombophlebitis, hypotension, tachycardia, peripheral vascular collapse, and convulsions in association with cardiorespiratory arrest


Respiratory depression (including apnea), cardiorespiratory arrest, laryngospasm, bronchospasm, hiccups, and dyspnea


Skeletal muscle hyperactivity (twitching), injury to nerves adjacent to injection site, and seizures


Emergence delirium, restlessness, and anxiety may occur, especially in the presence of postoperative pain


Nausea, emesis, abdominal pain, and liver function tests abnormal


Erythema, pruritus, urticaria, and cases of anaphylaxis have been reported rarely


Other adverse reactions include pain at injection site, salivation, headache, and rhinitis

For medical advice about adverse reactions contact your medical professional. To report SUSPECTED ADVERSE REACTIONS, contact JHP at 1-866-923-2547 or MEDWATCH at 1800-FDA-1088 (1-800-332-1088) or

Drug Abuse And Dependence

Controlled Substance-Brevital Sodium is a Schedule IV drug.

Brevital Sodium may be habit-forming.

Read the Brevital Sodium (methohexital sodium for injection) Side Effects Center for a complete guide to possible side effects


Prior chronic administration of barbiturates or phenytoin (e.g. for seizure disorder) appears to reduce the effectiveness of Brevital Sodium. Barbiturates may influence the metabolism of other concomitantly used drugs, such as phenytoin, halothane, anticoagulants, corticosteroids, ethyl alcohol, and propylene glycol-containing solutions.

This monograph has been modified to include the generic and brand name in many instances.

Last reviewed on RxList: 2/7/2014

Side Effects

Report Problems to the Food and Drug Administration


You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

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