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Brevital Sodium

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Brevital Sodium

Brevital Sodium Side Effects Center

Medical Editor: John P. Cunha, DO, FACOEP

Last reviewed on RxList 12/19/2015

Brevital Sodium (methohexital sodium for injection) is a barbiturate used to make you fall asleep before a surgery or other medical procedure. Brevital Sodium is usually given in combination with other types of anesthesia. Common side effects of Brevital Sodium include drowsiness, nausea, vomiting, stomach pain, chills or shivering, coughing, hiccups, muscle twitching, or mild skin rash or itching.

The dose of Brevital Sodium is individualized and is done in a clinical setting before a medical or surgical procedure. Brevital Sodium may interact with phenytoin, blood thinners, or steroids. Tell your doctor all medications you use. Brevital Sodium is not expected to be harmful to a fetus. Tell your doctor if you are pregnant or plan to become pregnant during treatment. This drug may pass into breast milk and may harm a nursing baby. Consult your doctor before breastfeeding.

Our Brevital Sodium (methohexital sodium for injection) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What is Patient Information in Detail?

Easy-to-read and understand detailed drug information and pill images for the patient or caregiver from Cerner Multum.

Brevital Sodium in Detail - Patient Information: Side Effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Tell your caregivers at once if you have any of these serious side effects:

  • severe burning or swelling where the medicine was injected;
  • seizure (convulsions);
  • numbness or tingly feeling;
  • feeling like you might pass out;
  • fast heart rate;
  • weak or shallow breathing; or
  • confusion, anxiety, or restless feeling when coming out of anesthesia.

Less serious side effects may include:

  • drowsiness;
  • nausea, vomiting, stomach pain;
  • chills or shivering;
  • coughing, hiccups;
  • muscle twitching; or
  • mild skin rash or itching.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Read the entire detailed patient monograph for Brevital Sodium (Methohexital Sodium for Injection)

What is Prescribing information?

The FDA package insert formatted in easy-to-find categories for health professionals and clinicians.

Brevital Sodium FDA Prescribing Information: Side Effects
(Adverse Reactions)


Side effects associated with Brevital Sodium are extensions of pharmacologic effects and include:


Circulatory depression, thrombophlebitis, hypotension, tachycardia, peripheral vascular collapse, and convulsions in association with cardiorespiratory arrest


Respiratory depression (including apnea), cardiorespiratory arrest, laryngospasm, bronchospasm, hiccups, and dyspnea


Skeletal muscle hyperactivity (twitching), injury to nerves adjacent to injection site, and seizures


Emergence delirium, restlessness, and anxiety may occur, especially in the presence of postoperative pain


Nausea, emesis, abdominal pain, and liver function tests abnormal


Erythema, pruritus, urticaria, and cases of anaphylaxis have been reported rarely


Other adverse reactions include pain at injection site, salivation, headache, and rhinitis

For medical advice about advers e reactions contact your medical professional. To report SUSPECTED ADVERSE REACTIONS, contact Par Pharmaceutical, Inc. at 1-800-828-9393 or FDA at 1-800-FDA-1088 (1-800-332-1088) or www.fda.gov/medwatch/.

Drug Abuse And Dependence

Controlled Substance

Brevital Sodium is a Schedule IV drug.

Brevital Sodium may be habit-forming.

Read the entire FDA prescribing information for Brevital Sodium (Methohexital Sodium for Injection)

Report Problems to the Food and Drug Administration


You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

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