July 27, 2016
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BSS Plus 250

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BSS Plus 250 mL

How Supplied


BSS PLUS is indicated for use as an intraocular irrigating solution during intraocular surgical procedures involving perfusion of the eye.


The solution should be used according to the standard technique employed by the operating surgeon. Use an administration set with an air-inlet in the plastic spike since the bottle does not contain a separate airway tube. Follow the directions for the particular administration set to be used. Insert the spike aseptically into the bottle through the center target area of the rubber stopper. Allow the fluid to flow to remove air from the tubing before intraocular irrigation begins. If a second bottle is necessary to complete the surgical procedure, ensure that the vacuum is vented from the second bottle BEFORE attachment to the administration set.


DIRECTIONS: Use Aseptic Technique

  1. Remove the blue flip-off seal from the BSS PLUS® (balanced salt solution) Part I (240 mL) bottle. Remove the blue flip-off seal from the BSS PLUS Part II (10 mL) vial. Prepare the stoppers on both parts by using sterile alcohol wipes.
  2. Peel open a BSS PLUS Vacuum Transfer Device package (supplied) and remove the sterile transfer spike.
    NOTE: This device is vented permitting air to enter vial during solution transfer, thereby preventing the creation of a vacuum inside the vial. An air-inlet filter is provided to protect the system. Do not remove the air-inlet filter.
  3. Remove protector from the white plastic piercing pin.
  4. Firmly grasp device from behind the flange and insert the white plastic piercing pin into the upright rubber stopper of the BSS PLUS Part II (10 mL) vial.
  5. Remove guard from filter needle. Firmly grasp vial in the palm of one hand and with thumb and index finger, hold plastic flange against top of vial.
  6. Invert vial and immediately insert filter needle into the outer target of the rubber stopper of the BSS PLUS Part I (240 mL) bottle. (See illustration.)
  7. Fluid will automatically transfer from the vial into the large vacuum bottle unless filter becomes occluded or loss of vacuum occurs. NOTE: An excess amount of BSS PLUS Part II is provided in each vial. A non-transferred solution residual of approximately 0.1 mL can be expected to remain in the vial.
  8. Immediately remove needle from the BSS PLUS® (balanced salt solution) Part I container and discard it after solution transfer has been completed.
  9. Place a sterile safety cap over the rubber stopper of Part I if the solution is not going to be used immediately. Mix the solution gently until uniform. Peel off the right-hand side of Part I bottle label (fully reconstituted BSS PLUS Solution). Record the patient's name and the date and time of reconstitution. BSS PLUS Solution is now ready for use.

Hanger Device - Illustration

CAUTION: Reconstituted BSS PLUS Solution must be used within six hours of mixing. Discard any solution which has aged beyond that time. Never use the same bottle of BSS PLUS Solution on more than one patient.

Alternative Transfer Method

If preferred, the contents of the BSS PLUS Part II component may be aspirated with an 18-gauge cannula attached to a 10 mL syringe and then transferred into the Part I bottle.


BSS PLUS is supplied in two packages for reconstitution prior to use: a 250 mL glass bottle containing 240 mL (Part I) and a 10 mL glass vial (Part II); both using grey butyl stoppers and aluminum seals with polypropylene flip-off caps. See the PRECAUTIONS section regarding reconstitution of the solution. NDC 0065-0800-25.

Storage: Store Part I and Part II at 2° - 25°C (36° - 77°F). DO NOT FREEZE. Discard prepared solution after six hours.

Alcon Laboratories, Inc., Fort Worth, Texas 76134 USA. FDA revision date: n/a

This monograph has been modified to include the generic and brand name in many instances.

Last reviewed on RxList: 10/30/2008

How Supplied

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