Buprenex (Buprenorphine) Drug Information: Description, User Reviews, Drug Side Effects, Interactions

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May 26, 2012

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Buprenex

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Buprenex®
(buprenorphine hydrochloride) Injectable

DRUG DESCRIPTION

Proprietary name: Buprenex

Established name: buprenorphine HCI

Route of administration: INTRAVENOUS (C38276), INTRAMUSCULAR (C28161)

Active ingredients (moiety): buprenorphine HCI (buprenorphine)

#	Strength	Form	Inactive ingredients
1	0.324 : 1	INJECTION, SOLUTION ( C42945)	anhydrous dextrose, water for injection, hydrochloric acid

Buprenex (buprenorphine hydrochloride) is a narcotic under the Controlled Substances Act due to its chemical derivation from thebaine. Chemically, it is 17-(cyclopropylmethyl)-α-(1,1-dimethylethyl)-4, 5-epoxy-18,19-dihydro-3-hydroxy-6-methoxy-α-methyl-6, 14- ethenomorphinan-7-methanol, hydrochloride [5α, 7α(S)]. Buprenorphine hydrochloride is a white powder, weakly acidic and with limited solubility in water. Buprenex (buprenorphine) is a clear, sterile, injectable agonist-antagonist analgesic intended for intravenous or intramuscular administration. Each ml of Buprenex contains 0.324 mg buprenorphine hydrochloride (equivalent to 0.3 mg buprenorphine), 50 mg anhydrous dextrose, water for injection and HCI to adjust pH. Buprenorphine hydrochloride has the molecular formula, C₂₉H₄₁NO₄HCI, and the following structure:

Buprenex (buprenorphine hydrochloride) structural formula illustration

What are the possible side effects of buprenorphine injection (Buprenex)?

Like other narcotic medicines, buprenorphine injection can slow your breathing. Death may occur if breathing becomes too weak.

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have any of these serious side effects:

slow or shallow breathing;
feeling light-headed, fainting;
confusion, unusual thoughts or behavior; or
nausea,...

Read All Potential Side Effects and See Pictures of Buprenex »

What are the precautions when taking buprenorphine (Buprenex)?

Before using buprenorphine, tell your doctor or pharmacist if you are allergic to it; or to adhesives; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: brain disorders (such as head injury, tumor, seizures), breathing problems (such as asthma, sleep apnea, chronic obstructive pulmonary disease-COPD), kidney disease, liver disease, mental/mood disorders (such as confusion, depression), personal or family history of regular use/abuse of drugs/alcohol, stomach/intestinal problems (such as blockage, constipation, diarrhea due to infection, paralytic ileus),...

Read All Potential Precautions of Buprenex »

Last reviewed on RxList: 4/22/2008
This monograph has been modified to include the generic and brand name in many instances.