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Buprenex

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Buprenex

Buprenex®
(buprenorphine hydrochloride) Injectable

DRUG DESCRIPTION

Proprietary name: Buprenex

Established name: buprenorphine HCI

Route of administration: INTRAVENOUS (C38276), INTRAMUSCULAR (C28161)

Active ingredients (moiety): buprenorphine HCI (buprenorphine)

# Strength Form Inactive ingredients
1 0.324 : 1 INJECTION, SOLUTION ( C42945) anhydrous dextrose, water for injection, hydrochloric acid

Buprenex (buprenorphine hydrochloride) is a narcotic under the Controlled Substances Act due to its chemical derivation from thebaine. Chemically, it is 17-(cyclopropylmethyl)-α-(1,1-dimethylethyl)-4, 5-epoxy-18,19-dihydro-3-hydroxy-6-methoxy-α-methyl-6, 14- ethenomorphinan-7-methanol, hydrochloride [5α, 7α(S)]. Buprenorphine hydrochloride is a white powder, weakly acidic and with limited solubility in water. Buprenex (buprenorphine) is a clear, sterile, injectable agonist-antagonist analgesic intended for intravenous or intramuscular administration. Each ml of Buprenex contains 0.324 mg buprenorphine hydrochloride (equivalent to 0.3 mg buprenorphine), 50 mg anhydrous dextrose, water for injection and HCI to adjust pH. Buprenorphine hydrochloride has the molecular formula, C29H41NO4HCI, and the following structure:

Buprenex (buprenorphine hydrochloride) structural formula illustration

What are the possible side effects of buprenorphine injection (Buprenex)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Like other narcotic medicines, buprenorphine can slow your breathing. Death may occur if breathing becomes too weak.

Call your doctor at once if you have a serious side effect such as:

  • weak or shallow breathing, feeling light-headed, fainting;
  • blue lips or fingernails;
  • confusion, feelings of extreme happiness;
  • fast or slow heart rate; or
  • urinating less...

Read All Potential Side Effects and See Pictures of Buprenex »

Last reviewed on RxList: 4/22/2008
This monograph has been modified to include the generic and brand name in many instances.

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Report Problems to the Food and Drug Administration

 

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.


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