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Brand Names: Busulfex, Myleran

Generic Name: busulfan (Pronunciation: bue SUL fan)

• What is busulfan (Busulfex)?
• What are the possible side effects of busulfan (Busulfex)?
• What is the most important information I should know about busulfan (Busulfex)?
• What should I discuss with my healthcare provider before using busulfan (Busulfex)?
• How should I take busulfan (Busulfex)?
• What happens if I miss a dose (Busulfex)?
• What happens if I overdose (Busulfex)?
• What should I avoid while using busulfan (Busulfex)?
• What other drugs will affect busulfan (Busulfex)?
• Where can I get more information?

What is busulfan (Busulfex)?

Busulfan is a cancer medication that interferes with the growth of cancer cells and slows their spread in the body.

Busulfan is used to treat the symptoms of chronic myelogenous leukemia (a type of blood cancer). Busulfan is not a cure for leukemia.

Busulfan may also be used for other purposes not listed in this medication guide.

What are the possible side effects of busulfan (Busulfex)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have a serious side effect such as:

• pale skin, easy bruising or bleeding (nosebleeds, bleeding gums);
• signs of infection such as fever, chills, sore throat, flu symptoms, loss of appetite, weight loss, mouth sores, unusual weakness;
• persistent cough, congestion, low fever, feeling short of breath (these symptoms may occur several months or years after using busulfan);
• weight gain, stomach swelling or tenderness, jaundice (yellowing of the skin or eyes);
• coughing up blood;
• stomach pain, vomiting, sharp chest pain, trouble breathing;
• blurred vision, eye pain, or seeing halos around lights;
• seizure (convulsions); or
• fever, sore throat, and headache with a severe blistering, peeling, and red skin rash.

Less serious side effects may include:

• missed menstrual periods; or
• darkened skin color.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What is the most important information I should know about busulfan (Busulfex)?

You should not use busulfan if you are allergic to it.

Do not use busulfan without telling your doctor if you are pregnant. It could harm the unborn baby. Use effective birth control, and tell your doctor if you become pregnant during treatment.

Before you receive busulfan, tell your doctor if you have a weak immune system, a seizure disorder, a history of head injury or breathing problems, or if you have recently received other cancer medications or radiation treatment.

Busulfan can lower blood cells that help your body fight infections. Your blood will need to be tested on a weekly or monthly basis. Your liver function may also need to be tested on a regular basis. Busulfan can have long-lasting effects on your body. Do not miss any follow-up visits to your doctor for blood or urine tests.

Contact your doctor at once if you develop signs of infection such as fever, chills, sore throat, flu symptoms, easy bruising or bleeding (nosebleeds, bleeding gums), weight loss, mouth sores, or unusual weakness.

Some people treated with busulfan have developed new forms of cancer. Talk to your doctor about your specific risks and benefits of using this medication.