April 29, 2017
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Butrans Patient Information including How Should I Take

What should I discuss with my health care provider before using this drug (Butrans)?

You should not use buprenorphine if you are allergic to it, or if you have:

  • asthma or severe breathing disorder; or
  • a bowel obstruction called paralytic ileus.

Do not use buprenorphine if you have used an MAO inhibitor such as furazolidone (Furoxone), isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam, Zelapar), or tranylcypromine (Parnate) in the last 14 days. Serious, life threatening side effects can occur if you use buprenorphine before the MAO inhibitor has cleared from your body.

To make sure you can safely use buprenorphine, tell your doctor if you have any of these other conditions:

  • COPD (chronic obstructive pulmonary disease), sleep apnea, or other breathing disorders;
  • a personal or family history of Long QT syndrome:
  • hepatitis B or C;
  • liver or kidney disease;
  • a thyroid disorder;
  • gallbladder disease;
  • curvature of the spine;
  • a history of head injury or brain tumor;
  • epilepsy or other seizure disorder;
  • Addison's disease or other adrenal gland disorders;
  • enlarged prostate, urination problems;
  • depression or other mental illness; or
  • a history of drug or alcohol addiction.

Buprenorphine may be habit-forming and should be used only by the person it was prescribed for. Never share buprenorphine with another person, especially someone with a history of drug abuse or addiction. Keep the medication in a place where others cannot get to it.

FDA pregnancy category C. It is not known whether buprenorphine will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using this medication.

Buprenorphine can pass into breast milk and may harm a nursing baby. You should not breast-feed while you are using buprenorphine.

Your dose needs may be different if you have recently used an opioid pain medicine and your body is tolerant to it. Opioids include Tylenol #3, Lortab, Vicodin, Exalgo, OxyContin, Percocet, Actiq, Duragesic, Methadose, Dolophine, Kadian, MS Contin, Oramorph, Opana, and many others. Talk with your doctor if you are not sure you are opioid-tolerant.

How should I use this drug (Butrans)?

Use exactly as prescribed. Never use buprenorphine in larger amounts, or for longer than recommended by your doctor. Follow the directions on your prescription label. Tell your doctor if the medicine seems to stop working as well in relieving your pain.

This medication comes with patient instructions for safe and effective use. Follow these directions carefully. Ask your doctor or pharmacist if you have any questions.

If you are switching to buprenorphine transdermal from another narcotic pain medicine, you may need to slowly stop using the other medicine. Follow your doctor's instructions.

Apply the skin patch only to clean, dry skin. Use only clear water to wash the skin before you apply a skin patch. Soaps or other chemicals could increase the amount of buprenorphine your skin absorbs.

Apply the patch to a flat and hairless area of the chest, back, side, or outer side of your upper arm. Wear the patch around the clock for 7 days. Never wear more than 1 buprenorphine skin patch at a time unless your doctor has told you to.

Do not use a buprenorphine transdermal skin patch if it has been cut or damaged.

After removing a skin patch fold it in half, sticky side in, and flush the patch down the toilet or use the Patch-Disposal Unit provided with this medication. Apply a new patch to a different skin area on the chest, back, side, or upper arm. Do not use the same skin area twice in a row.

Never share this medication with another person, even if they have the same symptoms you have.

Ask your doctor how to avoid withdrawal symptoms when you stop using buprenorphine.

Keep both used and unused buprenorphine skin patches out of the reach of children or pets. The amount of buprenorphine in a used skin patch could be fatal to a child or pet who accidentally sucks or chews on the patch. Seek emergency medical attention if this happens.

Keep track of how many skin patches have been used from each new package of this medication. Buprenorphine is a drug of abuse and you should be aware if any person in the household is using this medicine improperly or without a prescription.

Store at room temperature. Keep each patch in its foil pouch until you are ready to use it.

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Butrans - User Reviews

Butrans User Reviews

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Here is a collection of user reviews for the medication Butrans sorted by most helpful. Patient Discussions FAQs

Report Problems to the Food and Drug Administration


You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

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