Byetta (Exenatide Injection) Drug Overview of Side Effects and Precautions for Patients and Caregivers at RxList

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May 25, 2012

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Diabetic Home Care and Monitoring »

What is diabetes?

Diabetes mellitus is a condition in which the body does not produce enough insulin or the insulin that is produced is ineffective. Insulin is produced and secreted by the pancreas and is needed for the proper storage and utilization of nutrients (glucose, proteins, and fat) by the cells of the body. Insulin allows nutrients to enter the cells of the body. For example, insulin allows cells to remove glucose from the blood, and the glucose is used to generate the energy that is necessary to fuel the activities of the cells. When insulin is absent or ineffective and the cells receive inadequate amounts of glucose, the body releases more glucose into the blood in an attempt to overcome the block to glucose entering the cells. The additional glucose cannot penetrate the cells, of course, and the glucose levels in the blood rise. High levels of blood and urine glucose is what causes the symptoms and signs of diabetes. For more, please re...

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SIDE EFFECTS: Nausea, vomiting, diarrhea, nervousness or upset stomach may occur as your body adjusts to the medication. Nausea usually lessens as you continue to use exenatide. Other side effects include decreased appetite/food intake or decreased body weight. If any of these effects persist or worsen, contact your doctor or pharmacist promptly.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Rare but serious pancreas problems (pancreatitis) can occur while using exenatide. Get immediate medical attention if you develop severe/persistent stomach/abdominal pain, or persistent severe nausea/vomiting. Do not restart exenatide treatment without first talking with your doctor.

Tell your doctor immediately if this rare but serious side effect occurs: a change in the amount of your urine.

A very serious allergic reaction to this drug is unlikely, but seek immediate medical attention if it occurs. Symptoms of a serious allergic reaction may include: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

In the US -

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

PRECAUTIONS: Before using exenatide, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: kidney disease, severe stomach/intestinal disorders (e.g., digestion problems such as gastroparesis, or pancreatitis).

You may experience blurred vision, headache, dizziness, or drowsiness due to extremely low or high blood sugar levels. Do not drive, use machinery, or do any activity that requires alertness or clear vision until you are sure you can perform such activities safely. Limit alcoholic beverages since alcohol can affect your blood sugar.

Symptoms of high blood sugar (hyperglycemia) include thirst, increased urination, confusion, drowsiness, flushing, rapid breathing, or fruity breath odor. If these symptoms occur, tell your doctor immediately. Your medication dosage may need to be increased.

During times of severe stress, such as fever, infection, injury or surgery, it may be more difficult to control your blood sugar. Consult your doctor, as a change in your medication or how often you test your blood sugar may be required.

This medication should be used only when clearly needed during pregnancy. Discuss the risks and benefits with your doctor. Your doctor may substitute insulin for this drug during your pregnancy. Follow all instructions carefully.

It is unknown if this medication passes into breast milk, but it is unlikely to harm a nursing infant. Consult your doctor before breast-feeding.