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home > drugs a-z list > byetta (exenatide injection) drug center > byetta (exenatide injection) drug - overdosage and contraindications
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Diabetic Home Care and Monitoring »
What is diabetes?
Diabetes mellitus is a condition in which the body does not produce enough insulin or the insulin that is produced is ineffective. Insulin is produced and secreted by the pancreas and is needed for the proper storage and utilization of nutrients (glucose, proteins, and fat) by the cells of the body. Insulin allows nutrients to enter the cells of the body. For example, insulin allows cells to remove glucose from the blood, and the glucose is used to generate the energy that is necessary to fuel the activities of the cells. When insulin is absent or ineffective and the cells receive inadequate amounts of glucose, the body releases more glucose into the blood in an attempt to overcome the block to glucose entering the cells. The additional glucose cannot penetrate the cells, of course, and the glucose levels in the blood rise. High levels of blood and urine glucose is what causes the symptoms and signs of diabetes. For more, please re...
Byetta
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OVERDOSE
In a clinical study of BYETTA (exenatide injection) , three patients with type 2 diabetes each experienced a single overdose of 100 mcg SC (10 times the maximum recommended dose). Effects of the overdoses included severe nausea, severe vomiting, and rapidly declining blood glucose concentrations. One of the three patients experienced severe hypoglycemia requiring parenteral glucose administration. The three patients recovered without complication. In the event of overdose, appropriate supportive treatment should be initiated according to the patient's clinical signs and symptoms.
CONTRAINDICATIONS
Hypersensitivity
BYETTA (exenatide injection) is contraindicated in patients with prior severe hypersensitivity reactions to exenatide or to any of the product components.
Last reviewed on RxList: 12/15/2010
This monograph has been modified to include the generic and brand name in many instances.
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