Melissa Conrad Stöppler, MD
Melissa Conrad Stöppler, MD, is a U.S. board-certified Anatomic Pathologist with subspecialty training in the fields of Experimental and Molecular Pathology. Dr. Stöppler's educational background includes a BA with Highest Distinction from the University of Virginia and an MD from the University of North Carolina. She completed residency training in Anatomic Pathology at Georgetown University followed by subspecialty fellowship training in molecular diagnostics and experimental pathology.
William C. Shiel Jr., MD, FACP, FACR
Dr. Shiel received a Bachelor of Science degree with honors from the University of Notre Dame. There he was involved in research in radiation biology and received the Huisking Scholarship. After graduating from St. Louis University School of Medicine, he completed his Internal Medicine residency and Rheumatology fellowship at the University of California, Irvine. He is board-certified in Internal Medicine and Rheumatology.
- What is CA 125? What is a tumor marker?
- How is CA 125 measured?
- What is the normal range for CA 125?
- What does an elevated CA 125 level indicate, and how is the CA 125 test used?
- What conditions other than ovarian cancer can cause an increased CA 125?
- Is CA 125 testing useful as a cancer screening test?
What is CA 125? What is a tumor marker?
CA 125 is a protein that is a so-called tumor marker or biomarker, which is a substance that is found in greater concentration in tumor cells than in other cells of the body. In particular, CA 125 is present in greater concentration in ovarian cancer cells than in other cells. It was first identified in the early 1980s, and the function of the CA 125 protein is not currently understood. CA stands for cancer antigen.
How is CA 125 measured?
CA 125 is usually measured from a venous blood sample. It can also be measured in fluid from the chest or abdominal cavity. The tests currently in use are all based upon the use of an antibody that is directed against the CA 125 protein (monoclonal antibody technique).
In 1996, an improved version of the test was introduced and is sometimes denoted as CA 125 - II. The numerical figure of the second generation test results may be higher or lower than a first generation test. When comparing multiple test results over time, it can be important to know which method was used.
What is the normal range for CA 125?
The normal values for CA 125 may vary slightly among individual laboratories. In most laboratories, the normal value is 0-35 units/ml.
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