"The US Food and Drug Administration (FDA) has expanded the use of the cystic fibrosis (CF) drug Orkambi (Vertex Pharmaceuticals) to children aged 6 to 11 years who have two copies of the F508del mutation in the CF transmembrane conductance"...
(caffeine citrate) Injection, USP
(caffeine citrate) Oral Solution, USP
Both Caffeine Citrate injection, USP for intravenous administration and Caffeine Citrate Oral Solution, USP are clear, colorless, sterile, nonpyrogenic, preservative-free, aqueous solutions adjusted to pH 4.7. Each mL contains 20 mg caffeine citrate (equivalent to 10 mg of caffeine base) prepared in solution by the addition of 10 mg caffeine anhydrous to 5.0 mg citric acid monohydrate, 8.3 mg sodium citrate dihydrate and Water for Injection.
Caffeine, a central nervous system stimulant, is an odorless white crystalline powder o r granule, with a bitter taste. It is sparingly soluble in water and ethanol at room temperature. The chemical name of caffeine is 3 ,7 -dihydro-1 p3 ,7 -trimethyl-1H - purine-2,6-dione. In the presence of citric acid it forms caffeine citrate salt in solution. The structural formula and molecular weight of caffeine citrate follows.
What are the possible side effects of caffeine citrate (Cafcit)?
Get emergency medical help if your child has any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Stop using caffeine citrate and call your doctor at once if your child has any of these serious side effects:
- stomach pain, tenderness, bloating,
- constipation or diarrhea;
- green-colored vomit;
- blood in the stools;
- unusual weakness;
- seizure (convulsions);
- twitching or uncontrolled muscle movements; or
- fever, fast or slow heart...
What are the precautions when taking caffeine citrate (Cafcit)?
Before taking caffeine citrate, tell your doctor or pharmacist if your infant is allergic to it; or if your infant has any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.
Before using this medication, tell your doctor or pharmacist your infant's medical history, especially of: heart disease, kidney disease, liver disease, stomach problems (e.g., peptic ulcers, necrotizing enterocolitis), seizures.
Caution is advised when using this drug in infants because they may be more sensitive to its effects, especially the stimulant effects (e.g., trouble sleeping, restlessness, nervousness).
Older adults may be more sensitive to the side effects of this drug,...
Last reviewed on RxList: 7/1/2016
This monograph has been modified to include the generic and brand name in many instances.
Additional Cafcit Information
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
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