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Cafergot

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Cafergot

CAFERGOT®
(ergotamine tartrate and caffeine) Tablets, USP

Cafergot

WARNING: Serious and/or life-threatening peripheral ischemia has been associated with the coadministration of CAFERGOT® (ergotamine tartrate and caffeine) with potent CYP 3A4 inhibitors including protease inhibitors and macrolide antibiotics. Because CYP 3A4 inhibition elevates the serum levels of CAFERGOT® (ergotamine tartrate and caffeine) , the risk for vasospasm leading to cerebral ischemia and/or ischemia of the extremities is increased. Hence, concomitant use of these medications is contraindicated (see also CONTRAINDICATIONS and WARNINGS section).

DRUG DESCRIPTION

Each tablet for oral administration contains 1 mg ergotamine tartrate, USP, and 100 mg caffeine, USP.

ERGOTAMINE TARTRATE:

Ergotamine tartrate Structural Formula Illustration

Ergotaman-3',6',18-trione, 12'-hydroxy-2'-methyl-5'-(phenyl-methyl)-,(5' α)-, [R-(R*,R*)]-2,3- dihydroxy-butanedioate (2:1) (salt).

CAFFEINE:

Caffeine Structural Formula Illustration

1H-Purine-2,6-dione, 3,7-dihydro-1,3,7-trimethyl-.

Inactive ingredients include acacia, calcium carbonate, compressible sugar, confectioner's sugar (sucrose and corn starch), magnesium stearate, methylparaben, microcrystalline cellulose, povidone, propylparaben, sodium benzoate, sodium starch glycolate, starch (potato), sucrose, synthetic iron oxide, titanium dioxide and other ingredients.

What are the possible side effects of caffeine and ergotamine (Cafergot, Migergot)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Stop using caffeine and ergotamine and call your doctor at once if you have a serious side effect such as:

  • sudden numbness or weakness, especially on one side of the body;
  • sudden headache, confusion, problems with vision, speech, or balance;
  • fast or slow heart rate;
  • muscle pain in your arms or legs;
  • leg weakness;
  • numbness or tingling and a pale or...

Read All Potential Side Effects and See Pictures of Cafergot »

Last reviewed on RxList: 9/30/2008
This monograph has been modified to include the generic and brand name in many instances.

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Report Problems to the Food and Drug Administration

 

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.


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