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Caffeine and Sodium Benzoate

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Caffeine and Sodium Benzoate Injection

Indications
Dosage
How Supplied

INDICATIONS

Caffeine and Sodium Benzoate Injection has been used in conjunction with supportive measure to treat respiratory depression associated with overdosage with CNS depressant drugs (e.g., narcotic analgesics, alcohol). However, because of questionable benefit and transient action, most authorities believe caffeine and other analeptics should not be used in these conditions and recommend other supportive therapy.

DOSAGE AND ADMINISTRATION

Caffeine and Sodium Benzoate Injection (caffeine alkaloid) may be administered by intramuscular or slow intravenous injection Some clinicians suggest that when used as a mild CNS stimulant to overcome fatigue, oral doses of 100 200 mg of anhydrous caffeine are required. One manufacturer recommends that citrated caffeine administered orally in dosages of 65-325 mg (about 32-162 mg of anhydrous caffeine) 3 times daily. Another manufacturer recommends an oral dosage of 250 mg of anhydrous caffeine in an extended-release formulation once daily, but warns that the drug should not be administered less than 6 hours before retiring.

Analeptic use of caffeine is strongly discouraged by most clinicians. However, the manufacturer of Caffeine Sodium Benzoate Injection recommends intramuscular, or in emergency respiratory failure, intravenous injection of 500 mg of the drug (about 250 mg of anhydrous caffeine) or a maximum single dose of 1 gram (about 500 mg of anhydrous caffeine) for the treatment of respiratory depression associated with overdosage of CNS depressants, including narcotic analgesics and alcohol, and with electric shock.

The usual dose is 0.5 g (7½ grains) as frequently as directed by the physician. The maximum safe dose 0.5 g and the total dose in 24 hours should rarely exceed 2.5 g.

Parenteral drug products should be inspected visually for particulate matter prior to administration whenever solution and container permit.

HOW SUPPLIED

Caffeine and Sodium Benzoate Injection, USP (caffeine alkaloid) 250 mg/mL

NDC 0517-2502-102 mL Single Dose Vials

Packed in boxes of 10.

Store at controlled room temperature between 15°-30°C (59°-86°F).

Rev. 11/98. American Regent Laboratories Inc., Shirley, NY 11967. FDA revision date: n/a

Last reviewed on RxList: 9/30/2008
This monograph has been modified to include the generic and brand name in many instances.

Indications
Dosage
How Supplied
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