May 27, 2017
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Caffeine and Sodium Benzoate

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Caffeine and Sodium Benzoate Injection

Caffeine and Sodium Benzoate Side Effects Center

Medical Editor: John P. Cunha, DO, FACOEP

Last reviewed on RxList 4/28/2016

Caffeine and Sodium Benzoate Injection (caffeine alkaloid) is used along with supportive measure to treat respiratory depression associated with over dosage with CNS depressant drugs, such as narcotics. However, because of questionable benefit and transient action, most authorities believe caffeine and other analeptics should not be used in these conditions and recommend other supportive therapy. Caffeine and Sodium Benzoate Injection is available in generic form. Common side effects of Caffeine and Sodium Benzoate Injection include:

  • headache
  • excitement
  • agitation
  • restlessness
  • irritability
  • anxiety
  • hyperventilation
  • shortness of breath
  • visual disturbances
  • nerve sensitivity (increased sensitivity to touch or pain)
  • tingling in the hands and feet
  • ringing or buzzing in the ears (tinnitus)
  • hearing loss
  • trouble sleeping
  • muscle tremors or twitches
  • increased urination
  • rapid heart rate, and
    other cardiac arrhythmias

Recommended doses of caffeine and sodium benzoate injection vary from 65-325 mg 3 times daily, to 250 mg of anhydrous caffeine in an extended-release formulation once daily. Your doctor will determine the appropriate dose. Caffeine and sodium benzoate injection may interact with other drugs. Tell your doctor all medications and supplements you use. During pregnancy, caffeine and sodium benzoate injection should be used only if prescribed. Consult your doctor before breastfeeding.

Our Caffeine and Sodium Benzoate Injection (caffeine alkaloid) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What is Prescribing information?

The FDA package insert formatted in easy-to-find categories for health professionals and clinicians.

Caffeine and Sodium Benzoate FDA Prescribing Information: Side Effects
(Adverse Reactions)


No information provided.

Read the entire FDA prescribing information for Caffeine and Sodium Benzoate (Caffeine Alkaloid)

Report Problems to the Food and Drug Administration


You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

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