October 9, 2015
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Side Effects


Hypervitaminosis D is characterized by effects on the following organ system:


Impairment of renal function with polyuria, nocturia, polydipsia, hypercalciuria, reversible azotemia, hypertension, nephrocalcinosis, generalized vascular calcification, or irreversible renal insufficiency which may result in death.


Mental retardation.

Soft Tissues

Widespread calcification of the soft tissues, including the heart, blood vessels, renal tubules, and lungs.


Bone demineralization (osteoporosis) in adults occurs concomitantly.

Decline in the average rate of linear growth and increased mineralization of bones in infants and children (dwarfism), vague aches, stiffness, and weakness.


Nausea, anorexia, constipation.


Mild acidosis, anemia, weight loss.

Read the Calciferol (ergocalciferol) Side Effects Center for a complete guide to possible side effects


Mineral oil interferes with the absorption of fat-soluble vitamins, including vitamin D preparations.

Administration of thiazide diuretics to hypoparathyroid patients who are concurrently being treated with ergocalciferol (ergocalciferol) may cause hypercalcemia.

Read the Calciferol Drug Interactions Center for a complete guide to possible interactions

Last reviewed on RxList: 12/29/2008
This monograph has been modified to include the generic and brand name in many instances.

Side Effects

Report Problems to the Food and Drug Administration


You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

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