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Hypervitaminosis D is characterized by effects on the following organ system:

Renal

Impairment of renal function with polyuria, nocturia, polydipsia, hypercalciuria, reversible azotemia, hypertension, nephrocalcinosis, generalized vascular calcification, or irreversible renal insufficiency which may result in death.

CNS

Mental retardation.

Soft Tissues

Widespread calcification of the soft tissues, including the heart, blood vessels, renal tubules, and lungs.

Skeletal

Bone demineralization (osteoporosis) in adults occurs concomitantly.

Decline in the average rate of linear growth and increased mineralization of bones in infants and children (dwarfism), vague aches, stiffness, and weakness.

Gastrointestinal

Nausea, anorexia, constipation.

Metabolic

Mild acidosis, anemia, weight loss.

Mineral oil interferes with the absorption of fat-soluble vitamins, including vitamin D preparations.

Administration of thiazide diuretics to hypoparathyroid patients who are concurrently being treated with ergocalciferol (ergocalciferol) may cause hypercalcemia.

Last reviewed on RxList: 12/29/2008
This monograph has been modified to include the generic and brand name in many instances.