"The U.S. Food and Drug Administration yesterday approved Obizur [Antihemophilic Factor (Recombinant), Porcine Sequence] for the treatment of bleeding episodes in adults with acquired hemophilia A (acquired Factor VIII [FVII] deficiency).
Adverse effects of Calcijex (calcitriol injection) are, in general, similar to those encountered with excessive vitamin D intake. The early and late signs and symptoms of vitamin D intoxication associated with hypercalcemia include:
Polyuria, polydipsia, anorexia, weight loss, nocturia, conjunctivitis (calcific), pancreatitis, photophobia, rhinorrhea, pruritus, hyperthermia, decreased libido, elevated BUN, albuminuria, hypercholesterolemia, elevated SGOT and SGPT, ectopic calcification, hypertension, cardiac arrhythmias, nephrocalcinosis, sensory disturbance, dehydration, apathy, and rarely, overt psychosis.
Occasional mild pain on injection has been observed.
Rare cases of hypersensitivity reactions have been reported, including anaphylaxis.
Read the Calcijex Injection (calcitrol) Side Effects Center for a complete guide to possible side effects
Concomitant use of magnesium-containing preparations should be used with caution or avoided since such use may lead to the development of hypermagnesemia.
Corticosteroids with glucocorticoid activity may counteract the bone and mineral metabolism effects of vitamin D analogues.
Cytochrome P450 enzyme-inducing anticonvulsants such as carbamazepine, phenobarbital, and phenytoin may reduce the effects of vitamin D because they increase vitamin D catabolism.
Read the Calcijex Injection Drug Interactions Center for a complete guide to possible interactions
Last reviewed on RxList: 3/26/2012
This monograph has been modified to include the generic and brand name in many instances.
Additional Calcijex Injection Information
- Calcijex Injection Drug Interactions Center: calcitriol iv
- Calcijex Injection Side Effects Center
- Calcijex Injection Overview including Precautions
- Calcijex Injection FDA Approved Prescribing Information including Dosage
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
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