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Calcijex

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Calcijex Injection

SIDE EFFECTS

Adverse effects of Calcijex (calcitriol injection) are, in general, similar to those encountered with excessive vitamin D intake. The early and late signs and symptoms of vitamin D intoxication associated with hypercalcemia include:

Early

Weakness, headache, somnolence, nausea, vomiting, dry mouth, constipation, muscle pain, bone pain, metallic taste, anorexia, abdominal pain, and epigastric discomfort.

Late

Polyuria, polydipsia, anorexia, weight loss, nocturia, conjunctivitis (calcific), pancreatitis, photophobia, rhinorrhea, pruritus, hyperthermia, decreased libido, elevated BUN, albuminuria, hypercholesterolemia, elevated SGOT and SGPT, ectopic calcification, hypertension, cardiac arrhythmias, nephrocalcinosis, sensory disturbance, dehydration, apathy, and rarely, overt psychosis.

Occasional mild pain on injection has been observed.

Post-Marketing Experience

Rare cases of hypersensitivity reactions have been reported, including anaphylaxis.

Read the Calcijex Injection (calcitrol) Side Effects Center for a complete guide to possible side effects

DRUG INTERACTIONS

Concomitant use of magnesium-containing preparations should be used with caution or avoided since such use may lead to the development of hypermagnesemia.

Corticosteroids with glucocorticoid activity may counteract the bone and mineral metabolism effects of vitamin D analogues.

Cytochrome P450 enzyme-inducing anticonvulsants such as carbamazepine, phenobarbital, and phenytoin may reduce the effects of vitamin D because they increase vitamin D catabolism.

Read the Calcijex Injection Drug Interactions Center for a complete guide to possible interactions

Last reviewed on RxList: 3/26/2012
This monograph has been modified to include the generic and brand name in many instances.

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You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.


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