April 28, 2017
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Calcium Disodium Versenate

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Calcium Disodium Versenate

Calcium Disodium Versenate
(edetate calcium disodium) Injection,USP


Calcium Disodium Versenate (edetate calcium disodium injection) is capable of producing toxic effects which can be fatal. Lead encephalopathy is relatively rare in adults, but occurs more often in pediatric patients in whom it may be incipient and thus overlooked. The mortality rate in pediatric patients has been high. Patients with lead encephalopathy and cerebral edema may experience a lethal increase in intracranial pressure following intravenous infusion; the intramuscular route is preferred for these patients. In cases where the intravenous route is necessary, avoid rapid infusion. The dosage schedule should be followed and at no time should the recommended daily dose be exceeded.


Calcium Disodium Versenate (edetate calcium disodium injection, USP) is a sterile, injectable, chelating agent in concentrated solution for intravenous infusion or intramuscular injection. Each 5 ml ampul contains 1000 mg of edetate calcium disodium (equivalent to 200 mg/ml) in water for injection. Chemically, this product is called [[N,N' -1,2-ethanediyl-bis[N-(carboxymethyl)-glycinato]](4-)- N,N',O,O',ON,ON']-,disodium,hydrate, (OC-6-21)-Calciate(2-).

Structural Formula:

Calcium Disodium Versenate
  (edetate calcium disodium) Structural Formula Illustration

C10H12CaN2Na2O8• x H2O
Molecular weight 374.27 (anhydrous)

What are the possible side effects of edetate calcium disodium (Calcium Disodium Versenate)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Tell your caregivers at once if you have any of these serious side effects:

  • urinating less than usual or not at all;
  • drowsiness, confusion, mood changes, increased thirst, loss of appetite, nausea and vomiting;
  • swelling, weight gain, feeling short of breath;
  • feeling like you might pass out; or
  • fast, slow, or uneven heart rate.


Read All Potential Side Effects and See Pictures of Calcium Disodium Versenate »

Last reviewed on RxList: 11/26/2008
This monograph has been modified to include the generic and brand name in many instances.

Report Problems to the Food and Drug Administration


You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

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