April 30, 2017
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Calcium Gluconate

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Calcium Gluconate

Calcium Gluconate
Injection, USP 10%

Sterile, Nonpyrogenic
0.68 mOsmoI/mL 680 mOsmol/L
C a++ 0.465 mEq/mL pH (6.0-8.2)


CAUTION: For Intravenous Use. Not recommended for Intramuscular or Subcutaneous use.


Calcium Gluconate is the calcium salt of gluconic acid, an oxidation product of glucose, and contains 9.3% calcium, which is about one-third of the calcium in strength of calcium chloride USP. Since it is soluble to the extent of only one part in 30 parts of cold water, the 10% solution is supersaturated and is stabilized by the addition of calcium saccharate tetrahydrate 0.46% w/v (which supplies calcium 6.2%). Each mL contains 98 mg of calcium gluconatemonohydrate, 4.6 mg of calcium saccharate tetrahydrate, and Water for Injection USP, q.s. Each mL provides 9.3 mg (0.465 milliequivalents) of calcium.

The 100 mL Pharmacy Bulk Package contains many single doses for use in a pharmacy admixture program in the preparation of parenteral fluids. See directions for dispensing from the 100 mL Pharmacy Bulk Package. pH is adjusted with sodium hydroxide and/or hydrochloric acid.

The structural formula is:

Calcium Gluconate Structural Formula Illustration

What are the possible side effects of calcium gluconate ()?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Less serious side effects may include:

  • nausea or vomiting;
  • decreased appetite;
  • constipation;
  • dry mouth or increased thirst; or
  • increased urination.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at...

Read All Potential Side Effects and See Pictures of Calcium Gluconate »

Last reviewed on RxList: 4/2/2009
This monograph has been modified to include the generic and brand name in many instances.

Report Problems to the Food and Drug Administration


You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

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