CaloMist Nasal Spray (Cyanocobalamin) Drug Information: Description, User Reviews, Drug Side Effects, Interactions

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February 10, 2012

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CaloMist Nasal Spray User Reviews >>

CaloMist Nasal Spray

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CaloMist Nasal Spray
(cyanocobalamin, USP)

DRUG DESCRIPTION

Cyanocobalamin is a synthetic form of vitamin B₁₂ with activity equivalent to the endogenous form of vitamin B₁₂. The chemical name is α-(5,6-dimethylbenzimidazolyl) cyanocobamide. The cobalt content is 4.35%. The molecular formula is C₆₃H₈₈CoN₁₄O₁₄P, which corresponds to a molecular weight of 1355.4 and the following structural formula:

CaloMist Nasal Spray (cyanocobalamin, USP) Structural Formula Illustration

Cyanocobalamin occurs as dark red crystals, orthorhombic needles, or crystalline red powder and is very hygroscopic in the anhydrous form, and sparingly to moderately soluble in water (1:80). The pharmacologic activity of cyanocobalamin is destroyed by heavy metals (iron) and strong oxidizing or reducing agents (Vitamin C), but not by autoclaving for short periods of time (15-20 minutes) at 121° C. The vitamin B₁₂ coenzymes are very unstable in light.

Each bottle of CaloMist Nasal Spray contains cyanocobalamin, sodium chloride, sodium phosphate monobasic, benzyl alcohol, sodium hydroxide, and benzalkonium chloride in purified water with an attached spray pump unit.

What are the possible side effects of nasal cyanocobalamin (CaloMist, Nascobal)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have a serious side effect such as:

chest pain;
feeling short of breath, even with mild exertion;
swelling, rapid weight gain; or
unusual warmth, redness, or pain in an arm or leg.

Less serious side effects may include:

headache, dizziness,...

Read All Potential Side Effects and See Pictures of CaloMist Nasal Spray »

What are the precautions when taking cyanocobalamin (CaloMist Nasal Spray)?

Before using cyanocobalamin, tell your doctor or pharmacist if you are allergic to it; or to cobalt; or if you have any other allergies. Your doctor may recommend that you receive a smaller test dose before starting your regular dose. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: low potassium blood levels (hypokalemia), gout, a certain blood disorder (polycythemia vera), a certain eye disease (Leber's disease), other vitamin/mineral deficiencies (especially folic acid and iron).

Tell your doctor if you develop a stuffy or runny nose (e.g., due to a common cold or allergies) while...

Read All Potential Precautions of CaloMist Nasal Spray »

Last reviewed on RxList: 8/16/2007
This monograph has been modified to include the generic and brand name in many instances.