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Cantil

Peptic ulcer facts

  • Peptic ulcers are sores in the lining of the stomach or duodenum.
  • Peptic ulcer formation is related to H. pylori bacteria in the stomach and nonsteroidal anti-inflammatory medications (NSAIDs) in 50% of patients. For the remaining 50% there are miscellaneous or unknown causes.
  • Ulcer pain may not correlate with the presence or severity of ulceration.
  • The main symptom of peptic ulcer is upper abdominal pain which can be dull, sharp, or burning. (Bloating and burping are not symptoms of peptic ulcer, and vomiting, poor appetite, and nausea are uncommon symptoms of peptic ulcer.)
  • Diagnosis of ulcer is made with upper GI series or endoscopy.
  • Treatment of ulcers involves antibiotic combinations along with stomach acid suppression to eradicate H. pylori, eliminating precipitating factors such as NSAIDs and stomach acid suppression...

Cantil

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CLINICAL PHARMACOLOGY

CANTIL (mepenzolate bromide) diminishes gastric acid and pepsin secretion. CANTIL (mepenzolate bromide) also suppresses spontaneous contractions of the colon. Pharmacologically, it is a post-ganglionic parasympathetic inhibitor. Radiotracer studies in which CANTIL (mepenzolate bromide) -14C was used in animals and humans indicate the absorption following oral administration, as with other quaternary ammonium compounds, is low. Between 3 and 22% of an orally administered dose is excreted in the urine over a 5-day period, with the majority of the radioactivity appearing on Day 1. The remainder appears in the next 5 days in the feces and presumably has not been absorbed.

Last reviewed on RxList: 5/6/2009
This monograph has been modified to include the generic and brand name in many instances.

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