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Cantil

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Cantil

CLINICAL PHARMACOLOGY

CANTIL (mepenzolate bromide) diminishes gastric acid and pepsin secretion. CANTIL (mepenzolate bromide) also suppresses spontaneous contractions of the colon. Pharmacologically, it is a post-ganglionic parasympathetic inhibitor. Radiotracer studies in which CANTIL (mepenzolate bromide) -14C was used in animals and humans indicate the absorption following oral administration, as with other quaternary ammonium compounds, is low. Between 3 and 22% of an orally administered dose is excreted in the urine over a 5-day period, with the majority of the radioactivity appearing on Day 1. The remainder appears in the next 5 days in the feces and presumably has not been absorbed.

Last reviewed on RxList: 5/6/2009
This monograph has been modified to include the generic and brand name in many instances.

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