Signs and Symptoms

The signs and symptoms of overdosage are headache; nausea; vomiting; blurred vision; dilated pupils; hot, dry skin; dizziness; dryness of the mouth; difficulty in swallowing; and CNS stimulation. A curare-like action may occur (i.e., neuromuscular blockade leading to muscular weakness and possible paralysis).

Oral LD₅₀

The oral LD₅₀ is greater than 750 mg/kg in mice and greater than 1000 mg/kg in rats. Maximum Human Dose Recorded

The maximum human dose recorded is 375 to 500 mg in a 4-year-old child (no adverse effects reported) and 500 to 750 mg in a 30-year-old adult (resulted in death).

Dialysis

It is not known if the drug is dialyzable.

Treatment

Treatment should consist of gastric lavage, emetics, and activated charcoal. Sedatives (e.g., short-acting barbiturates, benzodiazepines) may be used for management of overt signs of excitement. If indicated, an appropriate parenteral cholinergic agent may be used as an antidote.

1. Glaucoma
2. Obstructive uropathy (for example, bladder neck obstruction due to prostatic hypertrophy)
3. Obstructive disease of the gastrointestinal tract (for example, pyloroduodenal stenosis, achalasia)
4. Paralytic ileus
5. Intestinal atony of the elderly or debilitated patient (See PRECAUTIONS, Geriatric Use)
6. Unstable cardiovascular status in acute gastrointestinal hemorrhage
7. Toxic megacolon complicating ulcerative colitis
8. Myasthenia gravis
9. Allergic or idiosyncratic reactions to CANTIL (mepenzolate bromide) or related compounds

Last reviewed on RxList: 5/6/2009
This monograph has been modified to include the generic and brand name in many instances.