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home > drugs a-z list > cantil (mepenzolate bromide) drug center > cantil (mepenzolate bromide) drug - overdosage and contraindications
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Cantil
Peptic ulcer facts
- Peptic ulcers are sores in the lining of the stomach or duodenum.
- Peptic ulcer formation is related to H. pylori bacteria in the stomach and nonsteroidal anti-inflammatory medications (NSAIDs) in 50% of patients. For the remaining 50% there are miscellaneous or unknown causes.
- Ulcer pain may not correlate with the presence or severity of ulceration.
- The main symptom of peptic ulcer is upper abdominal pain which can be dull, sharp, or burning. (Bloating and burping are not symptoms of peptic ulcer, and vomiting, poor appetite, and nausea are uncommon symptoms of peptic ulcer.)
- Diagnosis of ulcer is made with upper GI series or endoscopy.
- Treatment of ulcers involves antibiotic combinations along with stomach acid suppression to eradicate H. pylori, eliminating precipitating factors such as NSAIDs and stomach acid suppression...
Cantil
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OVERDOSE
Signs and Symptoms
The signs and symptoms of overdosage are headache; nausea; vomiting; blurred vision; dilated pupils; hot, dry skin; dizziness; dryness of the mouth; difficulty in swallowing; and CNS stimulation. A curare-like action may occur (i.e., neuromuscular blockade leading to muscular weakness and possible paralysis).
Oral LD50
The oral LD50 is greater than 750 mg/kg in mice and greater than 1000 mg/kg in rats. Maximum Human Dose Recorded
The maximum human dose recorded is 375 to 500 mg in a 4-year-old child (no adverse effects reported) and 500 to 750 mg in a 30-year-old adult (resulted in death).
Dialysis
It is not known if the drug is dialyzable.
Treatment
Treatment should consist of gastric lavage, emetics, and activated charcoal. Sedatives (e.g., short-acting barbiturates, benzodiazepines) may be used for management of overt signs of excitement. If indicated, an appropriate parenteral cholinergic agent may be used as an antidote.
CONTRAINDICATIONS
- Glaucoma
- Obstructive uropathy (for example, bladder neck obstruction due to prostatic hypertrophy)
- Obstructive disease of the gastrointestinal tract (for example, pyloroduodenal stenosis, achalasia)
- Paralytic ileus
- Intestinal atony of the elderly or debilitated patient (See PRECAUTIONS, Geriatric Use)
- Unstable cardiovascular status in acute gastrointestinal hemorrhage
- Toxic megacolon complicating ulcerative colitis
- Myasthenia gravis
- Allergic or idiosyncratic reactions to CANTIL (mepenzolate bromide) or related compounds
Last reviewed on RxList: 5/6/2009
This monograph has been modified to include the generic and brand name in many instances.
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