"VANCOUVER, British Columbia â€” There is a small but statistically significant increased risk for acute pancreatitis among the dipeptidyl peptidase-4 (DPP-4) inhibitor class of glucose-lowering agents used in type 2 diabetes treatment, a new meta-a"...
Signs and Symptoms
The signs and symptoms of overdosage are headache; nausea; vomiting; blurred vision; dilated pupils; hot, dry skin; dizziness; dryness of the mouth; difficulty in swallowing; and CNS stimulation. A curare-like action may occur (i.e., neuromuscular blockade leading to muscular weakness and possible paralysis).
The oral LD50 is greater than 750 mg/kg in mice and greater than 1000 mg/kg in rats. Maximum Human Dose Recorded
The maximum human dose recorded is 375 to 500 mg in a 4-year-old child (no adverse effects reported) and 500 to 750 mg in a 30-year-old adult (resulted in death).
It is not known if the drug is dialyzable.
Treatment should consist of gastric lavage, emetics, and activated charcoal. Sedatives (e.g., short-acting barbiturates, benzodiazepines) may be used for management of overt signs of excitement. If indicated, an appropriate parenteral cholinergic agent may be used as an antidote.
- Obstructive uropathy (for example, bladder neck obstruction due to prostatic hypertrophy)
- Obstructive disease of the gastrointestinal tract (for example, pyloroduodenal stenosis, achalasia)
- Paralytic ileus
- Intestinal atony of the elderly or debilitated patient (See PRECAUTIONS, Geriatric Use)
- Unstable cardiovascular status in acute gastrointestinal hemorrhage
- Toxic megacolon complicating ulcerative colitis
- Myasthenia gravis
- Allergic or idiosyncratic reactions to CANTIL (mepenzolate bromide) or related compounds
Last reviewed on RxList: 5/6/2009
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