Cantil (Mepenzolate Bromide) Drug Information: Side Effects and Drug Interactions

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May 26, 2012

Cantil

Peptic Ulcer »

Peptic ulcer facts

Peptic ulcers are sores in the lining of the stomach or duodenum.
Peptic ulcer formation is related to H. pylori bacteria in the stomach and nonsteroidal anti-inflammatory medications (NSAIDs) in 50% of patients. For the remaining 50% there are miscellaneous or unknown causes.
Ulcer pain may not correlate with the presence or severity of ulceration.
The main symptom of peptic ulcer is upper abdominal pain which can be dull, sharp, or burning. (Bloating and burping are not symptoms of peptic ulcer, and vomiting, poor appetite, and nausea are uncommon symptoms of peptic ulcer.)
Diagnosis of ulcer is made with upper GI series or endoscopy.
Treatment of ulcers involves antibiotic combinations along with stomach acid suppression to eradicate H. pylori, eliminating precipitating factors such as NSAIDs and stomach acid suppression...

Read the Peptic Ulcer article »

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SIDE EFFECTS

Precise frequency data from controlled clinical studies with CANTIL (mepenzolate bromide) are not available.

Gastrointestinal System: vomiting, nausea, constipation, loss of taste, bloated feeling, dry mouth

Central Nervous System: mental confusion, dizziness, weakness, drowsiness, headache, nervousness

Ophthalmologic: increased ocular tension, cycloplegia, blurred vision, dilation of the pupil

Dermatologic-Hypersensitivity: anaphylaxis, urticaria

Cardiovascular: tachycardia, palpitations

Genitourinary: urinary retention, urinary hesitancy

Miscellaneous: decreased sweating, drowsiness, insomnia, impotence, suppression of lactation

Drug Abuse And Dependence

Tolerance, abuse, or dependence has not been reported with CANTIL (mepenzolate bromide) .

DRUG INTERACTIONS

The following agents may increase certain actions or side effects of anticholinergic drugs: amantadine, antiarrhythmic agents of class I (e.g., quinidine), antihistamines, antipsychotic agents (e.g., phenothiazines), benzodiazepines, MAO inhibitors, narcotic analgesics (e.g., meperidine), nitrates and nitrites, sympathomimetic agents, tricyclic antidepressants, and other drugs having anticholinergic activity.

Anticholinergics antagonize the effects of antiglaucoma agents. Anticholinergic drugs in the presence of increased intraocular pressure may be hazardous when taken concurrently with agents such as corticosteroids. (See CONTRAINDICATIONS.)

Anticholinergic agents may affect gastrointestinal absorption of various drugs, such as slowly dissolving dosage forms of digoxin; increased serum digoxin concentrations may result. Anticholinergic drugs may antagonize the effects of drugs that alter gastrointestinal motility, such as metoclopramide. Because antacids may interfere with the absorption of anticholinergic agents, simultaneous use of these drugs should be avoided.

The inhibiting effects of anticholinergic drugs on gastric hydrochloric acid secretion are antagonized by agents used to treat achlorhydria and those used to test gastric secretion.

Last reviewed on RxList: 5/6/2009
This monograph has been modified to include the generic and brand name in many instances.