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Capastat Sulfate Side Effects Center
Medical Editor: John P. Cunha, DO, FACOEP
Capastat Sulfate (capremycin) for Injection is an antibiotic used to treat Mycobacterium tuberculosis. Capastat Sulfate is usually given after other tuberculosis medications have been tried without successful treatment of the infection. Common side effects of Capastat Sulfate include:
- skin rash
- body aches
- flu symptoms, and
- injection site reactions (pain, irritation, swelling, or a hard lump)
Capastat Sulfate may be administered intramuscularly or intravenously. The usual dose is 1 g daily (not to exceed 20 mg/kg/day) given intramuscularly or intravenously for 60 to 120 days, followed by 1 g by either route 2 or 3 times weekly. Capastat Sulfate may interact with other antibiotics, lithium, methotrexate, pain or arthritis medicines, medicines used to treat ulcerative colitis, medicines used to prevent organ transplant rejection, antiviral medicines, or cancer medicines. Tell your doctor all medications and supplements you use. During pregnancy, Capastat Sulfate should be used only if prescribed. It is unknown if this drug passes into breast milk. Consult your doctor before breastfeeding.
Our Capastat Sulfate (capremycin) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
What is Patient Information in Detail?
Easy-to-read and understand detailed drug information and pill images for the patient or caregiver from Cerner Multum.
Capastat Sulfate in Detail - Patient Information: Side Effects
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Stop using capreomycin and call your doctor at once if you have any of these serious side effects:
- urinating less than usual or not at all;
- changes in your hearing;
- spinning sensation, problems with balance;
- ringing or roaring sound in your ears; or
- low potassium (confusion, uneven heart rate, extreme thirst, increased urination, leg discomfort, muscle weakness or limp feeling).
Less serious side effects may include:
- mild skin rash;
- fever, chills, body aches, flu symptoms; or
- pain, swelling, or a hard lump where the injection was given.
This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect. You may report side effects to FDA at 1-800-FDA-1088.
Read the entire detailed patient monograph for Capastat Sulfate (Capreomycin for Injection)
What is Patient Information Overview?
A concise overview of the drug for the patient or caregiver from First DataBank.
Capastat Sulfate Overview - Patient Information: Side Effects
Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.
Tell your doctor immediately if any of these unlikely but serious side effects occur: change in the amount of urine, ringing in the ears, trouble hearing, dizziness.
Tell your doctor immediately if any of these rare but very serious side effects occur: muscle weakness/cramps, irregular heartbeat, easy bleeding/bruising.
A very serious allergic reaction to this drug is rare. However, seek immediate medical attention if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.
This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.
In the US -
Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.
Read the entire patient information overview for Capastat Sulfate (Capreomycin for Injection)
What is Prescribing information?
The FDA package insert formatted in easy-to-find categories for health professionals and clinicians.
Capastat Sulfate FDA Prescribing Information: Side Effects
Nephrotoxicity: In 36% of 722 patients treated with Capastat Sulfate (capreomycin for injection) , elevation of the BUN above 20 mg/100 mL has been observed. In many instances, there was also depression of PSP excretion and abnormal urine sediment. In 10% of this series, the BUN elevation exceeded 30 mg/100 mL.
Toxic nephritis was reported in 1 patient with tuberculosis and portal cirrhosis who was treated with Capastat Sulfate (capreomycin for injection) (1 g) and aminosalicylic acid daily for 1 month. This patient developed renal insufficiency and oliguria and died. Autopsy showed subsiding acute tubular necrosis.
Ototoxicity: Subclinical auditory loss was noted in approximately 11% of 722 patients undergoing treatment with Capastat Sulfate (capreomycin for injection) . This was a 5- to 10-decibel loss in the 4000- to 8000-CPS range. Clinically apparent hearing loss occurred in 3% of the 722 subjects. Some audiometric changes were reversible. Other cases with permanent loss were not progressive following withdrawal of Capastat Sulfate (capreomycin for injection) .
Tinnitus and vertigo have occurred.
Liver: Serial tests of liver function have demonstrated a decrease in BSP excretion without change in AST (SGOT) or ALT (SGPT) in the presence of preexisting liver disease. Abnormal results in liver function tests have occurred in many persons receiving Capastat Sulfate (capreomycin for injection) in combination with other antituberculosis agents that also are known to cause changes in hepatic function. The role of Capastat Sulfate (capreomycin for injection) in producing these abnormalities is not clear; however, periodic determinations of liver function are recommended.
Blood: Leukocytosis and leukopenia have been observed. The majority of patients treated have had eosinophilia exceeding 5% while receiving daily injections of Capastat Sulfate (capreomycin for injection) . This has subsided with reduction of the Capastat Sulfate dosage to 2 or 3 g weekly.
Pain and induration at the injection site have been observed. Excessive bleeding at the injection site has been reported. Sterile abscesses have been noted. Rare cases of thrombocytopenia have been reported.
Hypersensitivity:Urticaria and maculopapular skin rashes associated in some cases with febrile reactions have been reported when Capastat Sulfate (capreomycin for injection) and other antituberculosis drugs were given concomitantly.
Read the entire FDA prescribing information for Capastat Sulfate (Capreomycin for Injection)
Additional Capastat Sulfate Information
Capastat Sulfate - User Reviews
Capastat Sulfate User Reviews
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Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
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