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Capoten

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Capoten

CAPOTEN®
(captopril) Tablets, USP

WARNING

FETAL TOXICITY

  • When pregnancy is detected, discontinue Capoten as soon as possible.
  • Drugs that act directly on the renin-angiotensin system can cause injury and death to the developing fetus. See WARNINGS: Fetal Toxicity

DRUG DESCRIPTION

CAPOTEN® (captopril tablets, USP) is a specific competitive inhibitor of angiotensin I-converting enzyme (ACE), the enzyme responsible for the conversion of angiotensin I to angiotensin II.

CAPOTEN is designated chemically as 1-[(2S)-3-mercapto-2-methylpropionyl]-Lproline [MW 217.29] and has the following structure:

CAPOTEN® (Captopril Tablets, USP) Structural Formula Illustration

Captopril is a white to off-white crystalline powder that may have a slight sulfurous odor; it is soluble in water (approx. 160 mg/mL), methanol, and ethanol and sparingly soluble in chloroform and ethyl acetate.

CAPOTEN is available in potencies of 12.5 mg, 25 mg, 50 mg, and 100 mg as scored tablets for oral administration.

Inactive ingredients: microcrystalline cellulose, corn starch, lactose, and stearic acid.

What are the possible side effects of captopril (Capoten)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; severe stomach pain; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have a serious side effect such as:

  • feeling light-headed, fainting;
  • urinating more or less than usual, or not at all;
  • fever, chills, body aches, flu symptoms;
  • pale skin, feeling light-headed or short of breath, rapid heart rate, trouble concentrating;
  • easy bruising, unusual bleeding (nose, mouth, vagina, or rectum), purple or red...

Read All Potential Side Effects and See Pictures of Capoten »

What are the precautions when taking captopril (Capoten)?

Before taking captopril, tell your doctor or pharmacist if you are allergic to it; or to other ACE inhibitors (such as lisinopril); or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: history of an allergic reaction that included swelling of the face/lips/tongue/throat (angioedema), blood filtering procedures (such as LDL apheresis, dialysis), collagen vascular disease (such as lupus, scleroderma), high level of potassium in the blood.

This drug may make you dizzy. Do not drive, use machinery, or do any activity that requires alertness until you are...

Read All Potential Precautions of Capoten »

Last reviewed on RxList: 10/9/2012
This monograph has been modified to include the generic and brand name in many instances.

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Capoten - User Reviews

Capoten User Reviews

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Report Problems to the Food and Drug Administration

 

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.


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