Brand Names: Capozide 25/15, Capozide 25/25, Capozide 50/15, Capozide 50/25

Generic Name: hydrochlorothiazide and captopril (Pronunciation: hye droe klor oh THY a zide and KAP toe pril)

• What is hydrochlorothiazide and captopril (Capozide)?
• What are the possible side effects of hydrochlorothiazide and captopril (Capozide)?
• What is the most important information I should know about hydrochlorothiazide and captopril (Capozide)?
• What should I discuss with my healthcare provider before taking hydrochlorothiazide and captopril (Capozide)?
• How should I take hydrochlorothiazide and captopril (Capozide)?
• What happens if I miss a dose (Capozide)?
• What happens if I overdose (Capozide)?
• What should I avoid while taking hydrochlorothiazide and captopril (Capozide)?
• What other drugs will affect hydrochlorothiazide and captopril (Capozide)?
• Where can I get more information?

What is hydrochlorothiazide and captopril (Capozide)?

Hydrochlorothiazide is a thiazide diuretic (water pill) that helps prevent your body from absorbing too much salt, which can cause fluid retention.

Captopril is in a group of drugs called ACE inhibitors. ACE stands for angiotensin converting enzyme. Captopril lowers blood pressure and also relieves symptoms of fluid retention.

The combination of hydrochlorothiazide and captopril is used to treat hypertension (high blood pressure).

Hydrochlorothiazide and captopril may also be used for other purposes not listed in this medication guide.

Capozide 25-15 mg

square, white/orange specks, imprinted with CAPOZIDE 25/15

Captopril-HCTZ-25-15mg-MYL

round, white, imprinted with M 81

Captopril-HCTZ-25-25mg-MYL

round, peach, imprinted with M 83

Captopril-HCTZ-50-15mg-MYL

oblong, white, imprinted with M 84

Captopril-HCTZ-50-25mg-MYL

oblong, peach, imprinted with M 86

Captopril-Hydrochlorothiazide 25 mg-15 mg-TEV

round, white, imprinted with 93 176

Captopril-Hydrochlorothiazide 25 mg-25 mg-TEV

round, pink, imprinted with 93 177

Captopril-Hydrochlorothiazide 50 mg-15 mg-TEV

oval, white, imprinted with 93 181

Captopril-Hydrochlorothiazide 50 mg-25 mg-TEV

oval, white, imprinted with 93 182

What are the possible side effects of hydrochlorothiazide and captopril (Capozide)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; severe stomach pain; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have any of these serious side effects:

• high potassium (slow heart rate, weak pulse, muscle weakness, tingly feeling);
• low potassium (confusion, uneven heart rate, extreme thirst, increased urination, leg discomfort, muscle weakness or limp feeling);
• dry mouth, thirst, nausea, vomiting;
• feeling weak, drowsy, restless, or light-headed;
• a red, blistering, peeling skin rash;
• jaundice (yellowing of the skin or eyes);
• urinating less than usual or not at all;
• swelling, weight gain, feeling short of breath; or
• fever, chills, body aches, flu symptoms.

Less serious side effects may include:

• cough;
• dizziness, headache, tired feeling;
• blurred vision;
• diarrhea, constipation, upset stomach; or
• mild skin rash, increased sweating.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What is the most important information I should know about hydrochlorothiazide and captopril (Capozide)?

Do not use this medication if you are unable to urinate.

You should not use this medication if you are allergic to other ACE inhibitor, such as benazepril (Lotensin), fosinopril (Monopril), enalapril (Vasotec), lisinopril (Prinivil, Zestril), moexipril (Univasc), perindopril (Aceon), quinapril (Accupril), ramipril (Altace), or trandolapril (Mavik).

Before taking hydrochlorothiazide and captopril, tell your doctor if you have kidney disease (or are on dialysis), liver disease, congestive heart failure, asthma or allergies, gout, lupus, diabetes, or an allergy to sulfa drugs.

Captopril can cause birth defects in the baby if you take the medication during pregnancy. Do not use hydrochlorothiazide and captopril without telling your doctor if you are pregnant or planning a pregnancy.

Avoid the regular use of salt substitutes in your diet, and do not take potassium supplements while taking hydrochlorothiazide and captopril, unless your doctor has told you to.

Some things can cause your blood pressure to get too low. This includes vomiting, diarrhea, heavy sweating, heart disease, dialysis, a low-salt diet, or taking other diuretics (water pills). Follow your doctor's instructions about the type and amount of liquids you should drink while taking hydrochlorothiazide and captopril. Tell your doctor if you have a prolonged illness that causes diarrhea or vomiting.