Slideshows Images Quizzes

Carbaglu

Last reviewed on RxList: 1/26/2016
Carbaglu Side Effects Center

Last reviewed on RxList 1/22/2016

Carbaglu (carglumic acid) is a man-made form of a liver enzyme used to treat hyperammonemia, a urea cycle disorder caused by lack of a certain liver enzyme. Carbaglu is usually given with other medications to treat this lifelong disorder. Common side effects of Carbaglu include vomiting, diarrhea, stomach pain, headache, stuffy nose, sore throat, ear infection, changes in sense of taste, fever, infection, flu symptoms, weight loss, sleepiness, and skin rash.

The recommended initial dose of Carbaglu for acute hyperammonemia is 100 mg/kg/day to 250 mg/kg/day. Concomitant administration of other ammonia lowering therapies is recommended. Carbaglu may interact with other drugs. Tell your doctor all medications and supplements you use. It is unknown if Carbaglu will harm a fetus. Tell your doctor if you are pregnant or plan to become pregnant while using this medication. It is unknown if this drug passes into breast milk or if it could harm a nursing baby. Consult your doctor before breastfeeding.

Our Carbaglu (carglumic acid) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Carbaglu Consumer Information

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have a serious side effect such as:

  • fever, chills, body aches, flu symptoms, sores in your mouth and throat;
  • pale skin, feeling light-headed or short of breath, rapid heart rate, trouble concentrating; or
  • pain or fullness in your ear, hearing problems.

Less serious side effects may include:

  • vomiting, diarrhea, stomach pain;
  • headache; or
  • stuffy nose, sore throat.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Read the entire detailed patient monograph for Carbaglu (Carglumic Acid Tablets)

Carbaglu Professional Information

SIDE EFFECTS

Retrospective Case Series Experience

The most common adverse reactions (occurring in > 13% of patients), regardless of causality, are: Infections, vomiting, abdominal pain, pyrexia, tonsilitis, anemia, ear infection, diarrhea, nasopharyngitis and headache.

Table 1 summarizes adverse reactions occurring in 2 or more patients treated with Carbaglu® in the retrospective case series. Because these reactions were reported retrospectively, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure.

Table 1: Adverse Reactions Reported in > 2 Patients in the Retrospective Case Series treated with Carbaglu.

System Organ Class
Preferred Term
Number of Patients
(N) (%)
TOTAL 23 (100)
Blood and lymphatic system disorders
  Anemia 3 (13)
Ear and labyrinth disorders
  Ear infection 3 (13)
Gastrointestinal disorders
  Abdominal pain 4 (17)
  Diarrhea 3 (13)
  Vomiting 6 (26)
Dysgeusia 2 (9)
General disorders and administration site conditions
  Asthenia 2 (9)
  Hyperhidrosis 2 (9)
  Pyrexia 4 (17)
Infections and infestations
  Infections 3 (13)
  Influenza 2 (9)
  Nasopharyngitis 3 (13)
  Pneumonia 2 (9)
  Tonsillitis 4 (17)
Investigations
  Hemoglobin decreased 3(13)
  Weight decreased 2 (9)
Metabolism and nutrition disorders
  Anorexia 2 (9)
Nervous system disorders
  Headache 3 (13)
  Somnolence 2 (9)
Skin and subcutaneous tissue disorders
  Rash 2 (9)

Read the entire FDA prescribing information for Carbaglu (Carglumic Acid Tablets)

Related Resources for Carbaglu

Related Drugs

© Carbaglu Patient Information is supplied by Cerner Multum, Inc. and Carbaglu Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

Health Solutions From Our Sponsors