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Carbocaine

Introduction to dental medications

There are several types of medications that are used to manage a variety of diseases involving the oral cavity (mouth) that are part of good dental care. The medications discussed in this article have pharmacological properties that are used to treat conditions such as pain, anxiety, and infections, amongst others.

It is important to always communicate all dental signs and symptoms to your dentist, so that appropriate management and choice of medications can be made.

Medications used to control pain and anxiety

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Carbocaine

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Carbocaine™
(mepivacaine hydrochloride) Injection, USP

These solutions are not intended for spinal anesthesia or dental use

DRUG DESCRIPTION

Mepivacaine hydrochloride is 2-Piperidinecarboxamide, N-(2,6-dimethylphenyl)-1-methyl, monohydrochloride and has the following structural formula:

Carbocaine™ (Mepivacaine Hydrochloride) Structural Formula Illustration

C15H22N2O HCI

It is a white crystalline odorless powder, soluble in water, but very resistant to both acid and alkaline hydrolysis.

CARBOCAINE (mepivacaine) is a local anesthetic available as sterile isotonic solutions (clear, colorless) in concentrations of 1%, 1.5%, and 2% for injection via local infiltration, peripheral nerve block, and caudal and lumbar epidural blocks.

Mepivacaine hydrochloride is related chemically and pharmacologically to the amide-type local anesthetics. It contains an amide linkage between the aromatic nucleus and the amino group.

Composition of Available Solutions*

  1% Single-
Dose 30 mL Vial
mg/mL
1% Multiple-
Dose 50 mL Vial
mg/mL
1.5% Single-
Dose 30 mL Vial
mg/mL
2% Single-
Dose 20 mL Vial
mg/mL
2% Multiple-
Dose 50 mL
Vial mg/mL
Mepivacaine hydrochloride 10 10 15 20 20
Sodium chloride 6.6 7 5.6 4.6 5
Potassium chloride 0.3   0.3 0.3  
Calcium chloride 0.33   0.33 0.33  
Methylparaben   1     1
*In Water for Injection.

The pH of the solution is adjusted between 4.5 and 6.8 with sodium hydroxide or hydrochloric acid.

What are the possible side effects of mepivacaine (Carbocaine, Carbocaine HCl, Polocaine, Polocaine-MPF)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling or puffiness of your face, lips, tongue, or throat.

Tell your caregivers at once if you have a serious side effect such as:

  • weak or shallow breathing;
  • feeling like you might pass out;
  • sweating, anxiety, confusion;
  • blurred vision, ringing in your ears;
  • numbness or tingling around your mouth;
  • slow heart...

Read All Potential Side Effects and See Pictures of Carbocaine »

Last reviewed on RxList: 3/4/2010
This monograph has been modified to include the generic and brand name in many instances.

Report Problems to the Food and Drug Administration

 

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.


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