Carbocaine

Drug Description
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Carbocaine® 3% injection
(mepivacaine hydrochloride) Injection, USP

Carbocaine® 2%
with Neo-Cobefrin® 1:20,000 injection
(mepivacaine hydrochloride and levonordefrin) Injection, USP

DRUG DESCRIPTION

CARBOCAINE (mepivacaine hydrochloride), a tertiary amine used as a local anesthetic, is 1-methyl-2', 6' - pipecoloxylidide monohydrochloride with the following structural formula:

CARBOCAINE (mepivacaine hydrochloride) Structural Formula Illustration

It is a white, crystalline, odorless powder soluble in water, but very resistant to both acid and alkaline hydrolysis.

NEO-COBEFRIN, a sympathomimetic amine used as a vasoconstrictor in local anesthetic solution, is (-)-α -(1-Aminoethyl)-3, 4-dihydroxybenzyl alcohol with the following structural formula

NEO-COBEFRIN - Illustration

It is a white or buff-colored crystalline solid, freely soluble in aqueous solutions of mineral acids, but practically insoluble in water.

DENTAL CARTRIDGES MAY NOT BE AUTOCLAVED.

CARBOCAINE 3% injection and CARBOCAINE 2% with NEO-COBEFRIN 1:20,000 injection are sterile solutions for injection.

COMPOSITION: CARTRIDGE
Each mL contains: 2% 3%
Mepivacaine hydrochloride 20mg 30mg
Levonordefrin 0.05mg -
Sodium chloride 4mg 6mg
Potassium metabisulfite 1.2mg -
Edetate disodium 0.25mg -
Sodium hydroxide q.s. ad pH    
Hydrochloric acid 0.5mg -
Water for injections qs. ad. 1mL 1mL
The pH of the 2% cartridge solution is adjusted between 3.3 and 5.5 with NaOH.
The pH of the 3% cartridge solution is adjusted between 4.5 and 6.8 with NaOH.

Last updated on RxList: 7/16/2008


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