April 30, 2017
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Ketamine, an injectable anesthetic, has demonstrated a rapid an"...



(mepivacaine hydrochloride) Injection, USP

These solutions are not intended for spinal anesthesia or dental use


Mepivacaine hydrochloride is 2-Piperidinecarboxamide, N-(2,6-dimethylphenyl)-1-methyl, monohydrochloride and has the following structural formula:

Carbocaine™ (Mepivacaine Hydrochloride) Structural Formula Illustration


It is a white crystalline odorless powder, soluble in water, but very resistant to both acid and alkaline hydrolysis.

CARBOCAINE (mepivacaine) is a local anesthetic available as sterile isotonic solutions (clear, colorless) in concentrations of 1%, 1.5%, and 2% for injection via local infiltration, peripheral nerve block, and caudal and lumbar epidural blocks.

Mepivacaine hydrochloride is related chemically and pharmacologically to the amide-type local anesthetics. It contains an amide linkage between the aromatic nucleus and the amino group.

Composition of Available Solutions*

  1% Single-
Dose 30 mL Vial
1% Multiple-
Dose 50 mL Vial
1.5% Single-
Dose 30 mL Vial
2% Single-
Dose 20 mL Vial
2% Multiple-
Dose 50 mL
Vial mg/mL
Mepivacaine hydrochloride 10 10 15 20 20
Sodium chloride 6.6 7 5.6 4.6 5
Potassium chloride 0.3   0.3 0.3  
Calcium chloride 0.33   0.33 0.33  
Methylparaben   1     1
*In Water for Injection.

The pH of the solution is adjusted between 4.5 and 6.8 with sodium hydroxide or hydrochloric acid.

What are the possible side effects of mepivacaine (Carbocaine, Carbocaine HCl, Polocaine, Polocaine-MPF)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling or puffiness of your face, lips, tongue, or throat.

Tell your caregivers at once if you have a serious side effect such as:

  • weak or shallow breathing;
  • feeling like you might pass out;
  • sweating, anxiety, confusion;
  • blurred vision, ringing in your ears;
  • numbness or tingling around your mouth;
  • slow heart rate, weak pulse;
  • metallic taste in your...

Read All Potential Side Effects and See Pictures of Carbocaine »

Last reviewed on RxList: 2/8/2017
This monograph has been modified to include the generic and brand name in many instances.

Report Problems to the Food and Drug Administration


You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

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