"The U.S. Food and Drug Administration today approved Bridion (sugammadex) injection to reverse the effects of neuromuscular blockade induced by rocuronium bromide and vecuronium bromide, which are used during certain types of surgery in adu"...
(mepivacaine hydrochloride) Injection, USP
These solutions are not intended for spinal anesthesia or dental use
Mepivacaine hydrochloride is 2-Piperidinecarboxamide, N-(2,6-dimethylphenyl)-1-methyl, monohydrochloride and has the following structural formula:
It is a white crystalline odorless powder, soluble in water, but very resistant to both acid and alkaline hydrolysis.
CARBOCAINE (mepivacaine) is a local anesthetic available as sterile isotonic solutions (clear, colorless) in concentrations of 1%, 1.5%, and 2% for injection via local infiltration, peripheral nerve block, and caudal and lumbar epidural blocks.
Mepivacaine hydrochloride is related chemically and pharmacologically to the amide-type local anesthetics. It contains an amide linkage between the aromatic nucleus and the amino group.
Composition of Available Solutions*
Dose 30 mL Vial
Dose 50 mL Vial
Dose 30 mL Vial
Dose 20 mL Vial
Dose 50 mL
|*In Water for Injection.|
The pH of the solution is adjusted between 4.5 and 6.8 with sodium hydroxide or hydrochloric acid.
What are the possible side effects of mepivacaine (Carbocaine, Carbocaine HCl, Polocaine, Polocaine-MPF)?
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling or puffiness of your face, lips, tongue, or throat.
Tell your caregivers at once if you have a serious side effect such as:
- weak or shallow breathing;
- feeling like you might pass out;
- sweating, anxiety, confusion;
- blurred vision, ringing in your ears;
- numbness or tingling around your mouth;
- slow heart rate, weak pulse;
- metallic taste in your...
Last reviewed on RxList: 3/4/2010
This monograph has been modified to include the generic and brand name in many instances.
Additional Carbocaine Information
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
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