Cardura (Doxazosin Mesylate) Drug Information: Overdosage and Contraindications

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May 26, 2012

Cardura

Benign Prostatic Hyperplasia »

What is the prostate gland?

The prostate is a small organ about the size of a walnut. It lies below the bladder (where urine is stored) and surrounds the urethra (the tube that carries urine from the bladder). The prostate makes a fluid that helps to nourish sperm as part of the semen (ejaculatory fluid).

Prostate problems are common in men 50 and older. Most can be treated successfully without harming sexual function. A urologist is a specialist in diseases of the urinary system, including diagnosing and treating problems of the prostate gland.

How does the doctor detect prostate enlargement?

A doctor usually can detect an enlarged prostate by rectal exam. The doctor also may examine the urethra, prostate, and bladder using a cytoscope, an instrument that is inserted through the penis.

What is benign prostatic hyperplasia?

Benign prostatic hyperplasia is nonmalignant...

Read the Benign Prostatic Hyperplasia article »

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OVERDOSE

Experience with CARDURA (doxazosin mesylate) overdosage is limited. Two adolescents, who each intentionally ingested 40 mg CARDURA (doxazosin mesylate) with diclofenac or acetaminophen, were treated with gastric lavage with activated charcoal and made full recoveries. A two-year-old child who accidently ingested 4 mg CARDURA (doxazosin mesylate) was treated with gastric lavage and remained normotensive during the five-hour emergency room observation period. A six-month-old child accidentally received a crushed 1 mg tablet of CARDURA (doxazosin mesylate) and was reported to have been drowsy. A 32-year-old female with chronic renal failure, epilepsy, and depression intentionally ingested 60 mg CARDURA (doxazosin mesylate) (blood level = 0.9 jag/mL; normal values in hypertensives = 0.02 jag/mL); death was attributed to a grand mal seizure resulting from hypotension. A 39-year-old female who ingested 70 mg CARDURA (doxazosin mesylate) , alcohol, and Dalmane® (flurazepam) developed hypotension which responded to fluid therapy.

The oral LDso of doxazosin is greater than 1000 mg/kg in mice and rats. The most likely manifestation of overdosage would be hypotension, for which the usual treatment would be intravenous infusion of fluid. As doxazosin is highly protein bound, dialysis would not be indicated.

CONTRAINDICATIONS

CARDURA (doxazosin mesylate) is contraindicated in patients with a known sensitivity to quinazolines (e.g., prazosin, terazosin), doxazosin, or any of the inert ingredients.

Last reviewed on RxList: 11/22/2010
This monograph has been modified to include the generic and brand name in many instances.