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(doxazosin mesylate) Extended Release Tablets
CARDURA XL contains doxazosin mesylate which is a quinazoline compound with the chemical name 1-(4-amino-6,7-dimethoxy-2- quinazolinyl)-4-(1,4-benzodioxan-2-ylcarbonyl) piperazine methanesulfonate. The empirical formula for doxazosin mesylate is C23H25N5O5• CH4O3S and the molecular weight is 547.6. It has the following structure:
CARDURA XL is an extended release tablet for oral use and is designed to deliver 4 or 8 mg of doxazosin as the free base. Each 4 and 8 mg tablet contains 5.1 and 10.2 mg doxazosin mesylate (includes a 5% overage) to provide 4 and 8 mg doxazosin as a free base, respectively. The inactive ingredients for CARDURA XL are: polyethylene oxide, sodium chloride, hypromellose, red ferric oxide, titanium dioxide, magnesium stearate, cellulose acetate, Macrogol®, pharmaceutical glaze, and black iron oxide.
CARDURA XL System Components And Performance
CARDURA XL is similar in appearance to a conventional tablet. It consists, however, of an osmotically active drug core surrounded by a semipermeable membrane. The core itself is divided into two layers: an “active” layer containing the drug, and a “push” layer containing pharmacologically inert (but osmotically active) components. The membrane surrounding the tablet is permeable to water, but not to drug or osmotic excipients. As water from the gastrointestinal tract enters the tablet, pressure increases in the osmotic layer and “pushes” against the drug layer, resulting in the release of drug through a small, laser-drilled orifice in the membrane on the drug side of the tablet.
CARDURA XL utilizes GITS (Gastrointestinal Therapeutic System) which is designed to provide a controlled rate of delivery of doxazosin into the gastrointestinal lumen which is independent of pH or gastrointestinal (GI) motility. The function of CARDURA XL depends upon the existence of an osmotic gradient between the contents of the bi-layer core and fluid in the GI tract. Drug delivery is essentially constant as long as the osmotic gradient remains constant, and then gradually falls to zero. The biologically inert components of the tablet remain intact during GI transit and are eliminated in the feces as an insoluble shell.
What are the possible side effects of doxazosin (Cardura, Cardura XL)?
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have a serious side effect such as:
- feeling like you might pass out;
- fast or pounding heartbeats, fluttering in your chest;
- trouble breathing;
- swelling in your hands, ankles, or feet; or
- penis erection that is painful or lasts 4 hours or longer.
Less serious side effects may include:
- mild dizziness;
What are the precautions when taking doxazosin mesylate extended release tablets (Cardura XL)?
Before taking doxazosin, tell your doctor or pharmacist if you are allergic to it; or to other alpha blockers such as prazosin or terazosin; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.
Before using this medication, tell your doctor or pharmacist your medical history, especially of: stomach/intestine problems (such as short bowel syndrome, chronic constipation, narrow gut, slow gut movement), heart disease (such as congestive heart failure, angina, heart attack in last 6 months), liver disease, low blood pressure, certain eye problems (cataracts, glaucoma).
This drug may make you dizzy or drowsy. Do not drive, use machinery, or do any...
Last reviewed on RxList: 7/18/2016
This monograph has been modified to include the generic and brand name in many instances.
Additional Cardura XL Information
Cardura XL - User Reviews
Cardura XL User Reviews
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