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DOSAGE AND ADMINISTRATION
General Dosing Information
The initial dose of CARDURA XL, 4 mg given once daily, should be administered with breakfast. Depending on the patient's symptomatic response and tolerability, the dose may be increased to 8 mg, the maximum recommended dose. The recommended titration interval is 3–4 weeks. If CARDURA XL administration is discontinued for several days, therapy should be restarted using the 4 mg once daily dose. Tablets should be swallowed whole, and must not be chewed, divided, cut, or crushed.
Patients Switching From CARDURA To CARDURA XL
If switching from CARDURA immediate-release (IR) to CARDURA XL, therapy should be initiated with the lowest dose (4 mg once daily). Prior to starting therapy with CARDURA XL, the final evening dose of CARDURA should not be taken.
Concomitant Administration With PDE-5 Inhibitors
Concomitant administration of CARDURA XL with a PDE-5 inhibitor can result in additive blood pressure lowering effects and symptomatic hypotension; therefore, PDE-5 inhibitor therapy should be initiated at the lowest dose in patients taking CARDURA XL.
Dosage Forms And Strengths
White, round, film-coated tablets containing 4 mg and 8 mg doxazosin mesylate.
Storage And Handling
CARDURA XL (doxazosin mesylate extended release tablets) is available as 4 mg (white, imprinted with CXL 4) and 8 mg (white, imprinted with CXL 8) tablets.
Bottle of 30: 4 mg (NDC 0049-2710-30)
Bottle of 30: 8 mg (NDC 0049-2720-30)
Store at 25°C (77°F); excursions permitted to 15–30°C (59–86°F) [see USP Controlled Room Temperature].
Distributed by: Roerig, Division of Pfizer, NY, NY 10017. Revised: June 2015This monograph has been modified to include the generic and brand name in many instances.
Last reviewed on RxList: 7/18/2016
Additional Cardura XL Information
Cardura XL - User Reviews
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