Carisoprodol and Aspirin
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Carisoprodol and Aspirin
If severe reactions occur, discontinue Carisoprodol and Aspirin Tablets and initiate appropriate symptomatic and supportive therapy. The following side effects which have occurred with the administration of the individual ingredients alone may also occur with the combination.
Central Nervous System: Drowsiness is the most frequent complaint and along with other CNS effects may require dosage reduction. Observed less frequently are dizziness, vertigo and ataxia. Tremor, agitation, irritability, headache, depressive reactions, syncope and insomnia have been infrequent or rare.
Idiosyncratic: Idiosyncratic reactions are very rare. They are usually seen within the period of the first to fourth dose in patients having had no previous contact with the drug (see WARNINGS).
Allergic: Skin rash erythema multiforme, pruritus, eosinophilia and fixed drug eruptions with cross-reaction to meprobamate have been reported. If allergic reactions occur, discontinue Carisoprodol and Aspirin Tablets and treat symptomatically. In evaluating possible allergic reactions, also consider allergy to excipients.
Hematologic: No serious blood dyscrasias have been attributed to carisoprodol alone.
The most common adverse reactions associated with the use of aspirin have been gastrointestinal, including nausea, vomiting, gastritis, occult bleeding, constipation and diarrhea. Gastric erosion, angioedema, asthma rash, pruritus and urticaria have been reported less commonly. Tinnitus is a sign of high serum salicylate levels (see OVERDOSAGE).
Aspirin Intolerance: Allergic type reactions in aspirin-sensitive individuals may involve the respiratory tract or the skin. Symptoms of the former range from rhinorrhea and shortness of breath to severe asthma, and the latter may consist of urticaria, edema, rash or angioedema (giant hives). These may occur independently or in combination.
Drug Abuse And Dependence
Abuse: In clinical use, abuse has been rare.
Dependence: In clinical use, dependence with Carisoprodol and Aspirin Tablets have been rare and there have been no reports of significant abstinence signs, nevertheless, the following information on the individual ingredients should be kept in mind.
Carisoprodol: In dogs, no withdrawal symptoms occurred after abrupt cessation of carisoprodol from dosages as high as 1 gm/kg/ day. In a study in man, abrupt cessation of 100 mg/kg/day (about five times the recommended daily adult dosage) was followed in some subjects by mild withdrawal symptoms such as abdominal cramps, insomnia, chills, headache and nausea. Delirium and convulsions did not occur (see PRECAUTIONS).
Read the Carisoprodol and Aspirin (carisoprodol and aspirin) Side Effects Center for a complete guide to possible side effects »
Clinically important interactions may occur when certain drugs are administered concomitantly with aspirin or aspirin-containing drugs.
- Oral Anticoagulants - by interfering with platelet function or decreasing plasma prothrombin concentration, aspirin enhances the potential for bleeding in patients on anticoagulants.
- Methotrexate - aspirin enhances the toxic effects of the drug.
- Probenecid and Sulfinpyrazone - large doses of aspirin reduce the uricosuric effect of both drugs. Renal excretion of salicylate may also be reduced.
- Oral Antidiabetic Drug - enhancement of hypoglycemia may occur.
- Antacids - to the extent that they raise urinary pH, antacids may substantially decrease plasma salicylate concentrations; conversely, their withdrawal can result in a substantial increase.
- Ammonium Chloride - this and other drugs that acidify a relatively alkaline urine can elevate plasma salicylate concentrations.
- Ethyl Alcohol - enhanced aspirin-induced fecal blood loss has been reported.
- Corticosteroids - salicylate plasma levels may be decreased when adrenal corticosteroids are given, and may be increased substantially when they are discontinued.
Last reviewed on RxList: 5/28/2009
This monograph has been modified to include the generic and brand name in many instances.
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