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Long-term clinical trials have been conducted with dosages up to 200 mg of CASODEX (bicalutamide) daily and these dosages have been well tolerated. A single dose of CASODEX (bicalutamide) that results in symptoms of an overdose considered to be life threatening has not been established.
In the management of an overdose with CASODEX (bicalutamide) , vomiting may be induced if the patient is alert. It should be remembered that, in this patient population, multiple drugs may have been taken. Dialysis is not likely to be helpful since CASODEX (bicalutamide) is highly protein bound and is extensively metabolized. General supportive care, including frequent monitoring of vital signs and close observation of the patient, is indicated.
CASODEX (bicalutamide) is contraindicated in any patient who has shown a hypersensitivity reaction to the drug or any of the tablet's components. Hypersensitivity reactions including angioneurotic edema and urticaria have been reported [see SIDE EFFECTS].
CASODEX (bicalutamide) has no indication for women, and should not be used in this population.
CASODEX (bicalutamide) may cause fetal harm when administered to a pregnant woman. CASODEX (bicalutamide) is contraindicated in women, including those who are or may become pregnant. There are no studies in pregnant women using CASODEX (bicalutamide) . If this drug is used during pregnancy, or if the patient becomes pregnant while taking this drug, the patient should be appraised of the potential hazard to the fetus [see Use in Specific Populations].This monograph has been modified to include the generic and brand name in many instances.
Last reviewed on RxList: 3/13/2009
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