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No overdoses have been reported with CAYSTON (aztreonam for inhalation solution) in clinical trials to date. In clinical trials, 225 mg doses of CAYSTON (aztreonam for inhalation solution) via inhalation were associated with higher rates of drug-related respiratory adverse reactions, particularly cough. Since the peak plasma concentration of aztreonam following administration of CAYSTON (aztreonam for inhalation solution) (75 mg) is approximately 0.6 mcg/mL, compared to a serum concentration of 54 mcg/mL following administration of aztreonam for injection (500 mg), no systemic safety issues associated with CAYSTON (aztreonam for inhalation solution) overdose are anticipated.

CAYSTON is contraindicated in patients with a known allergy to aztreonam. 

Last reviewed on RxList: 3/11/2010
This monograph has been modified to include the generic and brand name in many instances.