April 28, 2017
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CeeNU Patient Information including How Should I Take

What should I discuss with my healthcare provider before taking lomustine (CeeNU)?

You should not use this medication if you are allergic to it.

If you have any of these other conditions, you may need a dose adjustment or special tests to safely use this medication:

  • bone marrow suppression;
  • liver disease;
  • kidney disease; or
  • a history of lung or breathing problems.

FDA pregnancy category D. Do not use lomustine if you are pregnant. It could harm the unborn baby. Use effective birth control, and tell your doctor if you become pregnant during treatment.

It is not known whether lomustine passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

How should I take lomustine (CeeNU)?

Take this medication exactly as prescribed by your doctor. Do not take it in larger amounts or for longer than recommended. Follow the directions on your prescription label.

Lomustine is usually taken once every 6 weeks. To get the correct dose, you may need to take 2 or more capsules that are different types and colors. Follow your doctor's dosing instructions very carefully.

Lomustine can cause nausea and vomiting but this should last less than 24 hours after your dose. You may have loss of appetite that lasts for several days.

Taking lomustine on an empty stomach may reduce nausea and vomiting. You may also be given anti-nausea medications. Call your doctor if you vomit right after taking a lomustine capsule.

Lomustine can lower the blood cells that help your body fight infections. This can make it easier for you to bleed from an injury or get sick from being around others who are ill.

To be sure your blood cells do not get too low, your blood will need to be tested weekly for at least 6 weeks after you take lomustine. This medication can have long-lasting effects on your body. Your kidneys, liver, and lung function may also need to be tested. Do not miss any follow-up visits to your doctor for blood or urine tests.

Store lomustine tablets at room temperature away from heat and moisture. Keep the bottle tightly closed until you are ready to take the medicine.

Wear disposable rubber gloves when you handle a lomustine capsule. Throw the gloves away after one use.

Do not use a lomustine capsule that has been accidentally opened or broken. The medicine from inside the capsule can be dangerous if it gets on your skin. If skin contact occurs, wash the area with soap and water. If you must handle a broken capsule, ask your doctor or pharmacist how to safely dispose of the capsule.

Side Effects Centers

Report Problems to the Food and Drug Administration


You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.


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