February 8, 2016
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Cefazolin

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Cefazolin Injection




Cefazolin Side Effects Center

Medical Editor: John P. Cunha, DO, FACOEP

Last reviewed on RxList 9/22/2015

Cefazolin and dextrose for injection is an antibiotic used to treat many different kinds of bacterial infections. Common side effects of Cefazolin and dextrose for injection include injection site reactions (pain, swelling, skin rash, or a hard lump), diarrhea, stomach pain, nausea, vomiting, loss of appetite, skin rash or itching, white patches or sores inside the mouth or on the lips, vaginal itching or discharge, or rectal itching.

The dose of cefazolin varies depending on the condition being treated and its severity. For mild infections, the recommended adult dose is 250 mg to 500 mg every 8 hours. For more severe infections the dose is 500 mg to 1 g every 6 to 8 hours. Cefazolin may interact with probenecid. Tell your doctor all medications and supplements you use. Tell your doctor if you are pregnant before receiving this medication. Cefazolin passes into breast milk in very low concentrations. Consult your doctor before breastfeeding.

Our cefazolin and dextrose for injection Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What is Prescribing information?

The FDA package insert formatted in easy-to-find categories for health professionals and clinicians.

Cefazolin FDA Prescribing Information: Side Effects
(Adverse Reactions)

SIDE EFFECTS

The following serious adverse reactions to cefazolin are described below and elsewhere in the labeling:

  • Hypersensitivity reactions [see WARNINGS AND PRECAUTIONS]
  • Clostridium difficile-associated diarrhea [see WARNINGS AND PRECAUTIONS]

Clinical Trials Experience

The following adverse reactions were reported from clinical trials:

Gastrointestinal

Diarrhea, oral candidiasis (oral thrush), mouth ulcers, vomiting, nausea, stomach cramps, epigastric pain, heartburn, flatus, anorexia and pseudomembranous colitis. Onset of pseudomembranous colitis symptoms may occur during or after antibacterial treatment [see WARNINGS AND PRECAUTIONS].

Allergic

Anaphylaxis, eosinophilia, urticaria, itching, drug fever, skin rash, Stevens-Johnson syndrome.

Hematologic

Neutropenia, leukopenia, thrombocytopenia, thrombocythemia.

Hepatic

Transient rise in SGOT, SGPT, and alkaline phosphatase levels has been observed. As with other cephalosporins, reports of hepatitis have been received.

Renal

As with other cephalosporins, reports of increased BUN and creatinine levels, as well as renal failure, have been received.

Local Reactions

Instances of phlebitis have been reported at site of injection. Some induration has occurred.

Other Reactions

Pruritus (including genital, vulvar and anal pruritus, genital moniliasis, and vaginitis). Dizziness, fainting, lightheadedness, confusion, weakness, tiredness, hypotension, somnolence and headache.

Cephalosporin-class Adverse Reactions

In addition to the adverse reactions listed above that have been observed in patients treated with cefazolin, the following adverse reactions and altered laboratory tests have been reported for cephalosporin-class antibacterials: Stevens-Johnson syndrome, erythema multiforme, toxic epidermal necrolysis, renal impairment, toxic nephropathy, aplastic anemia, hemolytic anemia, hemorrhage, hepatic impairment including cholestasis, and pancytopenia.

Read the entire FDA prescribing information for Cefazolin (Cefazolin and Dextrose for Injection)

Report Problems to the Food and Drug Administration

 

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.


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