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Discontinued Warning IconPlease Note: This Brand Name drug is no longer available in the US.
(Generic versions may still be available.)

Cefizox Side Effects Center

Medical Editor: John P. Cunha, DO, FACOEP

Cefizox (ceftizoxime for injection) is an antibiotic used to treat many kinds of bacterial infections, including severe or life-threatening forms. The brand name of this medication is discontinued, but generic versions may be available. Common side effects include pain, irritation, or hardening where the injection was given; stomach pain, nausea, vomiting; numbness or tingling; headache; or vaginal itching or discharge.

The usual adult dosage is 1 or 2 grams of Cefizox every 8 to 12 hours. Cefizox may interact with other antibiotics. Tell your doctor all medications and supplements you use. Cefizox is not expected to be harmful to a fetus. Tell your doctor if you are pregnant or plan to become pregnant during treatment. This drug can pass into breast milk and may harm a nursing baby. Consult your doctor before breastfeeding.

Our Cefizox (ceftizoxime for injection) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What is Patient Information in Detail?

Easy-to-read and understand detailed drug information and pill images for the patient or caregiver from Cerner Multum.

Cefizox in Detail - Patient Information: Side Effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have any of these serious side effects:

  • diarrhea that is watery or bloody;
  • severe pain, burning, irritation, or skin changes where the needle was placed;
  • skin rash, bruising, severe tingling, numbness, pain, muscle weakness;
  • uneven heartbeats;
  • fever, chills, body aches, flu symptoms;
  • easy bruising or bleeding, unusual weakness;
  • fever, sore throat, and headache with a severe blistering, peeling, and red skin rash;
  • seizure (black-out or convulsions); or
  • jaundice (yellowing of the eyes or skin).

Less serious side effects are more likely to occur, such as:

  • pain, irritation, or hardening where the injection was given;
  • stomach pain, nausea, vomiting;
  • numbness or tingling;
  • headache; or
  • vaginal itching or discharge.

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome. You may report side effects to FDA at 1-800-FDA-1088.

Read the entire detailed patient monograph for Cefizox (Ceftizoxime) »

What is Prescribing information?

The FDA package insert formatted in easy-to-find categories for health professionals and clinicians.

Cefizox FDA Prescribing Information: Side Effects
(Adverse Reactions)


Cefizox® (ceftizoxime for injection, USP) is generally well tolerated.

The most frequent adverse reactions (greater than 1 % but less than 5%) are:
Hypersensitivity: Rash, pruritus, fever.
Hepatic: Transient elevation in AST (SGOT), ALT (SGPT), and alkaline phosphatase.
Hematologic: Transienteosinophilia, thrombocytosis. Some individuals have developed a positive Coombs test.
Local†Injection site: Burning, cellulitis, phlebitis with IV administration, pain, induration, tenderness, paresthesia.

The less frequent adverse reactions (less than 1%) are:
Numbness and anaphylaxis have been reported rarely.
Hepatic: Elevation of bilirubin has been reported rarely.
Renal: Transient elevations of BUN and creatinine have been occasionally observed with Cefizox (ceftizoxime) .
Hematologic: Anemia, including hemolytic anemia with occasional fatal outcome, leukopenia, neutropenia, and thrombocytopenia have been reported rarely.
Urogenital: Vaginitis has occurred rarely.
Gastrointestinal: Diarrhea; nausea and vomiting have been reported occasionally.
Symptoms of pseudomembranous colitis can appear during or after antibiotic treatment (see WARNINGS).

In addition to the adverse reactions listed above which have been observed in patients treated with ceftizoxime, the following adverse reactions and altered laboratory tests have been reported for cephalosporin-class antibiotics:

Anticonvulsant therapy can be given if clinically indicated.

Read the entire FDA prescribing information for Cefizox (Ceftizoxime) »


Report Problems to the Food and Drug Administration


You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

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