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CEFOBID® (sterile cefoperazone) (cefoperazone), formerly known as cefoperazone sodium, is a sterile, semisynthetic, broad-spectrum, parenteral cephalosporin antibiotic for intravenous or intramuscular administration. It is the sodium salt of 7-[(R)-2-(4-ethyl-2,3-dioxo-1-piperazinecarboxamido)-2-(p-hydroxyphenyl)acetamido-3-[[(1-methyl-H-tetrazol-5-yl)thio]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate. Its chemical formula is C₂₅H₂₆N₉NaO₈S₂ with a molecular weight of 667.65. The structural formula is given below:

CEFOBID (sterile cefoperazone) contains 34 mg sodium (1.5 mEq) per gram. CEFOBID (sterile cefoperazone) is a white powder which is freely soluble in water. The pH of a 25% (w/v) freshly reconstituted solution varies between 4.5– 6.5 and the solution ranges from colorless to straw yellow depending on the concentration.

CEFOBID (sterile cefoperazone) in crystalline form is supplied in vials equivalent to 1 g or 2 g of cefoperazone.

A pharmacy bulk package is a container of a sterile preparation for parenteral use that contains many single doses.

This Pharmacy Bulk Package is for use in a pharmacy admixture service; it provides many single doses of cefoperazone for addition to suitable parenteral fluids in the preparation of admixtures for intravenous infusion. (See DOSAGE AND ADMINISTRATION, and Directions For Proper Use of Pharmacy Bulk Package.)

Last reviewed on RxList: 8/24/2009
This monograph has been modified to include the generic and brand name in many instances.