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Discontinued Warning IconPlease Note: This Brand Name drug is no longer available in the US.
(Generic versions may still be available.)

(cefotetan disodium) For Injection, USP


CEFOTAN™ (cefotetan for Injection, USP), as cefotetan diso dium, is a sterile, se misynthetic , broad-spectrum, beta-lac tamase resistant, cephalosporin (cephamyc in) antibacterial for parenteral administration. It is the disodium salt of [6 R-(6α,7α)]-7-[[[4 -(2-amino -1-car boxy-2-oxo ethylide ne )-1,3-dithietan-2yl]c arbo nyl]amino ]-7-me tho xy-3-[[(1-me thyl-1H-te trazo l-5-yl)thio]me thyl]-8-oxo5-thia-1-azabicyclo [4 .2.0 ]o ct-2-ene-2-carbo xylic acid. Structural fo rmula:

CEFOTAN™ (cefotetan disodium) Structural Formula Illustration

CEFOTAN™ (cefotetan for Injection, USP) is supplied in vials containing 80 mg (3.5 mEq) of sodium per gram of cefotetan activity. It is a white to pale yellow powder which is very soluble in water. Reconstituted solutions of CEFOTAN™ (cefotetan for Injection, USP) are intended for intravenous and intramusc ular administration. The solution varies from colorless to yellow depending on the concentration. The pH of freshly reconstituted solutions is usually between 4.5 to 6.5.

CEFOTAN™ (cefotetan for Injection, USP) is available in two vial strengths. Each 1 gram vial contains cefotetan disodium equivalent to 1 gram cefotetan activity. Each 2 gram vial contains cefotetan disodium equivalent to 2 g rams cefotetan activity.

What are the possible side effects of cefotetan (Cefotan)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have any of these serious side effects:

  • diarrhea that is watery or bloody;
  • chest pain;
  • fever, chills, body aches, flu symptoms;
  • easy bruising, unusual bleeding (nose, mouth, vagina, or rectum), purple or red pinpoint spots under your skin;
  • severe tingling, numbness, pain, muscle weakness;
  • seizure (convulsions);
  • pale skin, dark colored...

Read All Potential Side Effects and See Pictures of Cefotan »

What are the precautions when taking cefotetan (Cefotan)?

Before using cefotetan, tell your doctor or pharmacist if you are allergic to it; or to other cephalosporins; or to penicillins; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: kidney disease, liver disease, stomach/intestinal diseases (e.g., colitis), use/abuse of alcohol.

Avoid alcoholic beverages while taking this medication and for at least 3 days after finishing this medicine. Drinking alcohol may result in severe stomach upset/cramps, nausea, vomiting, headache, and flushing.

Kidney function declines as you grow older. This medication...

Read All Potential Precautions of Cefotan »

Last reviewed on RxList: 3/24/2017
This monograph has been modified to include the generic and brand name in many instances.

Report Problems to the Food and Drug Administration


You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

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