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The acute toxicity of cefotaxime (cefotaxime for injection) was evaluated in neonatal and adult mice and rats. Significant mortality was seen at parenteral doses in excess of 6000 mg/kg/day in all groups. Common toxic signs in animals that died were a decrease in spontaneous activity, tonic and clonic convulsions, dyspnea, hypothermia, and cyanosis.
Cefotaxime (cefotaxime for injection) sodium overdosage has occurred in patients. Most cases have shown no overt toxicity. The most frequent reactions were elevations of BUN and creatinine. Patients who receive an acute overdosage should be carefully observed and given supportive treatment.
Cefotaxime (cefotaxime for injection) for Injection USP and Dextrose Injection is contraindicated in patients who have shown hypersensitivity to cefotaxime (cefotaxime for injection) sodium or the cephalosporin group of antibiotics.
Solutions containing dextrose may be contraindicated in patients with hypersensitivity to corn products.This monograph has been modified to include the generic and brand name in many instances.
Last reviewed on RxList: 10/3/2007
Additional Cefotaxime Information
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