Cefuroxime (Cefuroxime Injection) Drug Information: Description, User Reviews, Drug Side Effects, Interactions

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February 9, 2012

Cefuroxime

Ear Infection (Otitis Media) »

Ear infection or inflammation (otitis media) facts

Otitis media (ear infection or inflammation) is the most common diagnosis in sick children in the U.S.
Otitis media features fever, ear pain, and a feeling of fullness in the ear; as well as fussiness and feeding problems in young children.
Otitis media is usually an infection and/or inflammation of the middle ear.
Ear infection or inflammation causes fluid buildup in the middle ear.
A cold or other respiratory infection can lead to ear infections or inflammation.
Exposure to other children's colds as often occurs in daycare centers, raises the risk of contracting otitis media (ear infection or inflammation).
Bottlefeeding increases the risk of ear infection or inflammation in babies.
Middle ear pus causes pain and temporary hearing loss.
Rupture of the eardrum allows the pus to drain into the ear canal.
Otitis ...

Read the Ear Infection (Otitis Media) article »

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Cefuroxime

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Cefuroxime (cefuroxime (cefuroxime injection) injection)
for Injection USP and Dextrose Injection USP

To reduce the development of drug-resistant bacteria and maintain the effectiveness of Cefuroxime (cefuroxime (cefuroxime injection) injection) for Injection USP and Dextrose Injection USP and other antibacterial drugs, Cefuroxime (cefuroxime (cefuroxime injection) injection) for Injection USP and Dextrose Injection USP should be used only to treat or prevent infections that are proven or strongly suspected to be caused by bacteria.

DRUG DESCRIPTION

Cefuroxime (cefuroxime (cefuroxime injection) injection) for Injection USP and Dextrose Injection USP is a sterile, nonpyrogenic, single use, packaged combination of Cefuroxime Sodium USP (crystalline) and Dextrose Injection USP (diluent) in the DUPLEX sterile container. The DUPLEX Container is a flexible dual chamber container.

The drug chamber is filled with sterile crystalline Cefuroxime (cefuroxime (cefuroxime injection) injection) for Injection USP, a semisynthetic, broad-spectrum, cephalosporin antibiotic for parenteral administration. It is the sodium salt of (6R,7R)-7-[2-(2-furyl)glyoxylamido]-3-(hydroxymethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate, 7²-(Z)-(O-methyloxime), carbamate (ester).

Cefuroxime (cefuroxime (cefuroxime injection) injection) Sodium USP has the following structural formula:

Cefuroxime Sodium Structural Formula Illustration

The empirical formula is C₁₆H₁₅N₄NaO₈S, representing a molecular weight of 446.4.

Cefuroxime (cefuroxime (cefuroxime injection) injection) contains approximately 54.2 mg (2.4 mEq) of sodium per gram of cefuroxime (cefuroxime (cefuroxime injection) injection) activity.

The diluent chamber contains Dextrose Injection USP. The concentration of Hydrous Dextrose USP has been adjusted to render the reconstituted drug product iso-osmotic. Dextrose Injection USP is sterile, nonpyrogenic, and contains no bacteriostatic or antimicrobial agents.

Hydrous Dextrose USP has the following structural (molecular) formula:

Hydrous Dextrose Structural Formula Illustration

The molecular weight of Hydrous Dextrose USP is 198.17.

Dextrose hydrous USP has been added to the diluent to adjust osmolality (approximately 1.45 g and 2.05 g to 750 mg and 1.5 g dosages, respectively).

After removing the peelable foil strip, activating the seals, and thoroughly mixing, the reconstituted drug product is intended for single intravenous use. When reconstituted, the approximate osmolality of the reconstituted solution for Cefuroxime (cefuroxime (cefuroxime injection) injection) for Injection USP and Dextrose Injection USP is 290 mOsmol/kg.

The DUPLEX Container is Latex-free, PVC-free, and Di (2-ethylhexyl) phthalate (DEHP)-free.

The DUPLEX dual chamber container is made from a specially formulated material. The product (diluent and drug) contact layer is a mixture of thermoplastic rubber and a polypropylene ethylene copolymer that contains no plasticizers. The safety of the container system is supported by USP biological evaluation procedures.

What are the precautions when taking cefuroxime injection (Cefuroxime)?

Before using cefuroxime, tell your doctor or pharmacist if you are allergic to it; or to other cephalosporins; or to penicillins; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: kidney disease, liver disease, stomach/intestinal diseases (e.g., colitis).

Kidney function declines as you grow older. This medication is removed by the kidneys. Therefore, elderly people may be at greater risk for side effects while using this drug.

Tell your doctor if you are pregnant before using this medication.

This medication passes into breast milk and...

Read All Potential Precautions of Cefuroxime »

Last reviewed on RxList: 4/10/2008
This monograph has been modified to include the generic and brand name in many instances.