August 24, 2016
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Celebrex

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Celebrex




Overdosage
Contraindications

OVERDOSE

Symptoms following acute NSAID overdosages have been typically limited to lethargy, drowsiness, nausea, vomiting, and epigastric pain, which have been generally reversible with supportive care. Gastrointestinal bleeding has occurred. Hypertension, acute renal failure, respiratory depression, and coma have occured, but were rare [see WARNINGS AND PRECAUTIONS].

No overdoses of CELEBREX were reported during clinical trials. Doses up to 2400 mg/day for up to 10 days in 12 patients did not result in serious toxicity. No information is available regarding the removal of celecoxib by hemodialysis, but based on its high degree of plasma protein binding ( > 97%) dialysis is unlikely to be useful in overdose.

Manage patients with symptomatic and supportive care following an NSAID overdosage. There are no specific antidotes. Consider emesis and/or activated charcoal (60 to 100 grams in adults, 1 to 2 grams per kg of body weight in pediatric patients) and/or osmotic cathartic in symptomatic patients seen within four hours of ingestion or in patients with a large overdosage (5 to 10 times the recommended dosage). Forced diuresis, alkalinization of urine, hemodialysis, or hemoperfusion may not be useful due to high protein binding.

For additional information about overdosage treatment contact a poison control center (1-800-222-1222).

CONTRAINDICATIONS

CELEBREX is contraindicated in the following patients:

  • Known hypersensitivity (e.g., anaphylactic reactions and serious skin reactions) to celecoxib, any components of the drug product [see WARNINGS AND PRECAUTIONS].
  • History of asthma, urticaria, or other allergic-type reactions after taking aspirin or other NSAIDs. Severe, sometimes fatal, anaphylactic reactions to NSAIDs, have been reported in such patients [see WARNINGS AND PRECAUTIONS].
  • In the setting of coronary artery bypass graft (CABG) surgery [see WARNINGS AND PRECAUTIONS].
  • In patients who have demonstrated allergic-type reactions to sulfonamides.
This monograph has been modified to include the generic and brand name in many instances.

Last reviewed on RxList: 6/7/2016

Overdosage
Contraindications

Celebrex - User Reviews

Celebrex User Reviews

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