Celebrex (Celecoxib) Drug Information: Overdosage and Contraindications

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May 26, 2012

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Psoriatic Arthritis »

Psoriatic arthritis facts

About one in 10 people with psoriasis also develop inflammation of joints (psoriatic arthritis).
The first appearance of the skin disease (psoriasis) can be separated from the onset of joint disease (arthritis) by years.
Psoriatic arthritis belongs to a group of arthritis conditions that cause inflammation of the spine (spondyloarthropathies).
Patients with psoriatic arthritis can develop inflammation of tendons, cartilage, eyes, lung lining, and, rarely, the aorta.
The arthritis of psoriatic arthritis is treated independently of the psoriasis, with exercise, ice applications, medications, and surgery.

What is psoriatic arthritis?

Psoriatic arthritis is a chronic disease characterized by a form of inflammation of the skin (psoriasis) and joints (arthritis). P...

Read the Psoriatic Arthritis article »

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OVERDOSE

No overdoses of CELEBREX (celecoxib) were reported during clinical trials. Doses up to 2400 mg/day for up to 10 days in 12 patients did not result in serious toxicity. Symptoms following acute NSAID overdoses are usually limited to lethargy, drowsiness, nausea, vomiting, and epigastric pain, which are generally reversible with supportive care. Gastrointestinal bleeding can occur. Hypertension, acute renal failure, respiratory depression and coma may occur, but are rare. Anaphylactoid reactions have been reported with therapeutic ingestion of NSAIDs, and may occur following an overdose.

Patients should be managed by symptomatic and supportive care following an NSAID overdose. There are no specific antidotes. No information is available regarding the removal of celecoxib by hemodialysis, but based on its high degree of plasma protein binding ( > 97%) dialysis is unlikely to be useful in overdose. Emesis and/or activated charcoal (60 to 100 g in adults, 1 to 2 g/kg in children) and/or osmotic cathartic may be indicated in patients seen within 4 hours of ingestion with symptoms or following a large overdose. Forced diuresis, alkalinization of urine, hemodialysis, or hemoperfusion may not be useful due to high protein binding.

CONTRAINDICATIONS

CELEBREX (celecoxib) is contraindicated:

In patients with known hypersensitivity to celecoxib, aspirin, or other NSAIDs.
In patients who have demonstrated allergic-type reactions to sulfonamides.
In patients who have experienced asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs. Severe anaphylactoid reactions to NSAIDs, some of them fatal, have been reported in such patients [see WARNINGS AND PRECAUTIONS].
For the treatment of peri-operative pain in the setting of coronary artery bypass graft (CABG) surgery [see WARNINGS AND PRECAUTIONS].

Last reviewed on RxList: 4/4/2011
This monograph has been modified to include the generic and brand name in many instances.