November 25, 2015
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Celestone Soluspan

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Celestone Soluspan

Celestone Soluspan Side Effects Center

Medical Editor: John P. Cunha, DO, FACOEP

Last reviewed on RxList 7/15/2015

Celestone Soluspan (betamethasone sodium phosphate and betamethasone acetate) is a corticosteroid used to treat chronic or long-term inflammation associated with multiple conditions including severe allergies, dermatological diseases, endocrine disorders, gastrointestinal diseases, hematologic disorders, neoplastic diseases, nervous system disorders, ophthalmologic diseases, renal diseases, respiratory diseases and rheumatic disorders, and others that may not be listed. Celestone Soluspan is available in generic form. Common side effects of Celestone Soluspan include acne, increased hunger, weight gain, mood or behavior changes, upset stomach, bone loss, eye changes, slowing of growth, trouble sleeping, excess stomach acid or heartburn, high blood sugar, irregular menstrual periods, and bloating. Long-term use of Celestone Soluspan can lead to suppression of your adrenal glands and cause fatigue, lethargy, low blood pressure, and electrolyte imbalances.

Dose of Celestone Soluspan is based on the individual patient and the condition that is being treated. Celestone Soluspan may interact with diuretics (water pills), antibiotics, warfarin, anti-diabetic agents, oral contraceptives, ketoconazole, non-steroidal anti-inflammatory drugs (NSAIDs), cyclosporine and digitalis. Tell your doctor all medications you are taking. Celestone Soluspan should be used during pregnancy only if prescribed. It could cause harm the fetus. Infants born to mothers who have received corticosteroids during pregnancy should be monitored for signs of hypoadrenalism. Celestone Soluspan passes into breast milk and could cause unwanted side effects for a nursing infant. Discuss breast-feeding with your doctor.

Our Celestone Soluspan Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What is Prescribing information?

The FDA package insert formatted in easy-to-find categories for health professionals and clinicians.

Celestone Soluspan FDA Prescribing Information: Side Effects
(Adverse Reactions)


(listed alphabetically, under each subsection)

Allergic Reactions

Anaphylactoid reaction, anaphylaxis, angioedema.


Bradycardia, cardiac arrest, cardiac arrhythmias, cardiac enlargement, circulatory collapse, congestive heart failure, fat embolism, hypertension, hypertrophic cardiomyopathy in premature infants, myocardial rupture following recent myocardial infarction (see WARNINGS), pulmonary edema, syncope, tachycardia, thromboembolism, thrombophlebitis, vasculitis.


Acne, allergic dermatitis, cutaneous and subcutaneous atrophy, dry scaly skin, ecchymoses and petechiae, edema, erythema, hyperpigmentation, hypopigmentation, impaired wound healing, increased sweating, rash, sterile abscess, striae, suppressed reactions to skin tests, thin fragile skin, thinning scalp hair, urticaria.


Decreased carbohydrate and glucose tolerance, development of cushingoid state, glucosuria, hirsutism, hypertrichosis, increased requirements for insulin or oral hypoglycemic adrenocortical and pituitary unresponsiveness (particularly in times of stress, as in trauma, surgery, or illness), suppression of growth in pediatric patients.

Fluid and Electrolyte Disturbances

Congestive heart failure in susceptible patients, fluid retention, hypokalemic alkalosis, potassium loss, sodium retention.


Abdominal distention, bowel/bladder dysfunction (after intrathecal administration), elevation in serum liver enzyme levels (usually reversible upon discontinuation), hepatomegaly, increased appetite, nausea, pancreatitis, peptic ulcer with possible perforation and hemorrhage, perforation of the small and large intestine (particularly in patients with inflammatory bowel disease), ulcerative esophagitis.


Negative nitrogen balance due to protein catabolism.


Aseptic necrosis of femoral and humeral heads, calcinosis (following intra-articular or intralesional use), Charcot-like arthropathy, loss of muscle mass, muscle weakness, osteoporosis, pathologic fracture of long bones, postinjection flare (following intra-articular use), steroid myopathy, tendon rupture, vertebral compression fractures.


Convulsions, depression, emotional instability, euphoria, headache, increased intracranial pressure with papilledema (pseudotumor cerebri) usually following discontinuation of treatment, insomnia, mood swings, neuritis, neuropathy, paresthesia, personality changes, psychic disorders, vertigo. Arachnoiditis, meningitis, paraparesis/paraplegia, and sensory disturbances have occurred after intrathecal administration (see WARNINGS, Neurologic section).


Exophthalmos, glaucoma, increased intraocular pressure, posterior subcapsular cataracts, rare instances of blindness associated with periocular injections.


Abnormal fat deposits, decreased resistance to infection, hiccups, increased or decreased motility and number of spermatozoa, malaise, moon face, weight gain.

Read the entire FDA prescribing information for Celestone Soluspan (Betamethasone Injectable Suspension)

Report Problems to the Food and Drug Administration


You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

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